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Clinical trial condition

alpha 1-Antitrypsin Deficiency

Explore clinical trials studying alpha 1-Antitrypsin Deficiency. Study availability and eligibility vary by location and protocol.

100 public trials 19 recruiting studies
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alpha 1-Antitrypsin Deficiency trial results

Completed

Phase II/III Study of an Alpha-1 Proteinase Inhibitor (Kamada-API) in Individuals With Alpha-1 Antitrypsin Deficiency

NCT00460096

Conditions
Alpha 1-Antitrypsin Deficiency, Chronic Disease, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, +14 more
Locations
  • National Jewish Medical and Research Center Denver, Colorado, United States
  • University of Florida School of Medicine Gainesville, Florida, United States
  • The University of Texas Health Center at Tyler Tyler, Texas, United States
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Active, Not Recruiting

Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)

NCT01983241

Conditions
Chronic Disease, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, +14 more
Locations
  • Grifols Investigative Site Phoenix, Arizona, United States
  • Grifols Investigative Site Gainesville, Florida, United States
  • Grifols Investigative Site Leesburg, Florida, United States
  • Grifols Investigative Site Miami, Florida, United States
View all 52 locations
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Active, Not Recruiting

Study of BMN 349 Single Dose in PiZZ and PiMZ/MASH Adult Participants

NCT06738017

Conditions
Alpha 1-Antitrypsin Deficiency, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, +9 more
Locations
  • University of California, San Diego San Diego, California, United States
  • Saint Louis University St Louis, Missouri, United States
  • Medpace Clinical Pharmacology Unit Cincinnati, Ohio, United States
  • The Medical University of South Carolina Charleston, South Carolina, United States
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Active, Not Recruiting

Alpha-1 Antitrypsin Deficiency Adult Liver Study

NCT02014415

Conditions
Alpha-1 Antitrypsin Deficiency, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, +10 more
Locations
  • University of California San Diego, California, United States
  • Boston University School of Medicine Boston, Massachusetts, United States
  • Saint Louis University St Louis, Missouri, United States
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Active, Not Recruiting

A Phase 1b/2a, Open-label Single Ascending Doses and Multiple Ascending Doses Study in Participants With Pi*ZZ AATD

NCT06405633

Conditions
Alpha-1 Antitrypsin Deficiency, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, +9 more
Locations
  • St. Vincent's Hospital, Melbourne Fitzroy, Victoria, Australia
  • Dalhousie University - Queen Elizabeth II Health Sciences Centre Halifax, Nova Scotia, Canada
  • Inspiration Research Limited Toronto, Ontario, Canada
  • Turku University Hospital Turku, Finland
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Active, Not Recruiting

Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema

NCT05897424

Conditions
Alpha 1-Antitrypsin Deficiency, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, +9 more
Locations
  • UAB Lung Health Center- Site Number : 105 Birmingham, Alabama, United States
  • St Joseph's Hospital and Medical Center- Site Number : 126 Phoenix, Arizona, United States
  • David Geffen School of Medicine at UCLA- Site Number : 124 Los Angeles, California, United States
  • University of California Davis Medical Center- Site Number : 110 Sacramento, California, United States
View all 40 locations
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Active, Not Recruiting

Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease

NCT05297812

Conditions
Alpha 1-Antitrypsin Deficiency, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, +10 more
Locations
  • University of Alabama at Birmingham Birmingham, Alabama, United States
  • University of California - Los Angeles Los Angeles, California, United States
  • National Jewish Health Denver, Colorado, United States
  • University of Chicago Chicago, Illinois, United States
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Active, Not Recruiting

An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease

NCT05899673

Conditions
Alpha1-Antitrypsin Deficiency, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Digestive System Diseases, +9 more
Locations
  • UCSD Altman Clinical and Translational Research Institute La Jolla, California, United States
  • Stanford Medicine Outpatient Center Redwood City, California, United States
  • UF Clinical and Translational Science Institute Gainesville, Florida, United States
  • University Of Iowa Hospitals And Clinics Iowa City, Iowa, United States
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