Whole Body Vibration Therapy in Boys With Duchenne Muscular Dystrophy

Post-Study Completion Note: Given competition for enrollment in other DMD trials and burden from daily home WBVT training, it was not feasible to study WBVT in the trial setting, nor is it likely to be a feasible modality for optimizing musculoskeletal health in routine care.

Inclusion criteria

• Diagnosis of Duchenne muscular dystrophy confirmed by at least one of the following:

• Dystrophin immunofluorescence and/or immunoblot showing complete dystrophin deficiency, and clinical presentation consistent with typical DMD
• Positive gene deletion test (missing one or more exons) in the central rod domain (exons 25-60) of dystrophin, where reading frame can be predicted as "out-of-frame", and clinical presentation consistent with typical DMD
• Complete dystrophin gene sequencing showing an alteration (point mutation, duplication, or other mutation resulting in a stop codon mutation) definitively associated with DMD, and clinical presentation consistent with typical DMD
• Age between 5 - 14 yrs old (inclusive)
• Positive Gower sign (indicating ability to rise from the floor & presence of proximal muscle weakness).
• Able to walk 10 meters in <12 seconds
• Able to stand upon WBVT plate (with knees flexed) for entire treatment protocol (i.e. 15-minutes)
• Stable absolute dose of glucocorticoids (i.e. prednisone or deflazacort) for at least 3 months prior
• Stable absolute doses of all medication that may affect muscle function (i.e. coenzyme Q10, green tea extract, creatine, arginine, glutamine, nutritional supplements, etc.) for at least 3 months prior
• Stable absolute dose of all medication that may affect bone metabolism (i.e. vitamin D and calcium supplementation) for at least 3 months prior

Exclusion criteria

• Clinical presentation, genetic testing and/or muscle biopsy consistent with Becker muscular dystrophy
• History of recent surgery (within past 6-months)
• History of a recent fracture (long-bone or vertebral) within past 6-months.
• Acute inflammatory processes of lower extremities (e.g. cellulitis, etc) due to risk of pain and/or worsening inflammatory process
• History of venous thrombosis (theoretically risk of inducing thromboembolic event).
• History of kidney or bladder stones
• History of uncontrolled seizures or severe migraines
• History of cardiac arrhythmia
• Intracranial pathology or hardware (e.g. ventriculoperitoneal shunt, cochlear implant).
• Use of any investigational or experimental products within last 6-months and/or concomitant participation in another study
• Inability or refusal to follow the study requirements (e.g. autism, severe cognitive or behaviour problems)
• Inability or refusal to provide informed consent (parent) and/or assent (child)