Pulmonary and Upper Limb Functions in Duchenne Muscular Dystrophy

Although it is known that the functions of pulmonary and upper limb is affected in late stage of Duchenne Muscular Dystrophy (DMD) negatively, the investigators do not have clear information about its early stage. The aim of this study was to investigate the differences in pulmonary and upper limb functions between children with DMD in early stage and healthy peers.

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Key information

Conditions

Duchenne Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Genetic Diseases, X-Linked Muscular Diseases Muscular Disorders, Atrophic Muscular Dystrophies Muscular Dystrophy, Duchenne Musculoskeletal Diseases Nervous System Diseases Neuromuscular Diseases Respiratory Function Test Upper Limb Function

Age range

5 year–10 year

Sex eligibility

Male

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

children with DMD was;

age between 5-10 years
being on treatment with corticosteroids for more than 6 months
being at Level I according to Brooke Upper and Lower Extremity Classification Systems

Healthy peers;

age between 5-10 years
not having any diagnosed disease

Exclusion criteria

Children has undergo surgery and disease affect upper extremity or pulmonary function in last six months.

Treatment and study plan

The Performance of Upper Limb Questionnaire (PUL)

Other

Other names: Pulmonary Function Test (PFT)

Primary outcomes

Pulmonary Function Test (PFT)

Time frame: 5 minutes

The pulmonary function tests of the participants were evaluated with a spirometry. The child was asked to perform the spirometric tests for three times with maximum effort. The child was motivated before each attempt for stronger and longer expiration.The result of Pulmonary function Test were recorded.
The Performance Upper Limb (PUL)

Time frame: 15 minutes

Upper limb functions of participants were evaluated with The Performance of Upper Limb (PUL) scale. This scale, which was shown to be reliable in DMD, has 22 items in total. It consists of 3 different levels of function: high, mid, and distal. PUL also has four items determining timed performance.

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Official study title

The Comparison of Pulmonary and Upper Extremity Functions Between Children With Duchenne Muscular Dystrophy and Healthy Peers

Important dates

Study start: 2017
Primary completion: 2017
Study completion: 2018
First posted: Jun 12, 2018
Registry last updated: Jun 12, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed