Peak Cough Flow and Cough Clearance in Patients With Muscular Dystrophy

This study is to determine whether physiologic measures (peak cough flow, measures of respiratory muscle strength including MIP, MEP ,SNIP, and spirometry) can predict spontaneous cough clearance (as measured by a nuclear medicine study) in children with neuromuscular disease. It will also determine whether airway clearance is augmented by high frequency chest wall oscillation.

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Key information

Conditions

Duchenne Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Genetic Diseases, X-Linked Muscular Diseases Muscular Disorders, Atrophic Muscular Dystrophies Muscular Dystrophy, Duchenne Musculoskeletal Diseases Nervous System Diseases Neuromuscular Diseases

Age range

6 year–21 year

Sex eligibility

Male

Study type

Observational

Primary location

Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 6-21; able to cooperate with study procedures
Duchenne Muscular Dystrophy OR Becker Muscular Dystrophy

Exclusion criteria

Need for mechanical ventilation during the day
Recent (within 2 weeks) lower respiratory tract infection

Treatment and study plan

Primary outcomes

Spontaneous cough clearance

Time frame: Assessed at multiple time points over 30 minutes

Sponsors and collaborators

Lead sponsor

University of Pittsburgh

Other

Collaborators

Respirtech, Inc.

Registry information

Official study title

Pilot Study of Cough Peak Flow And Airway Clearance in Pediatric Patients With Neuromuscular Disease

Important dates

Study start: 2014
Primary completion: 2021
Study completion: 2021
First posted: Jan 13, 2014
Registry last updated: Feb 5, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed