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Completed

NCT Number: NCT07729631

Establishing the Glycaemic Index of Vegetable Smoothies

Glycaemic responses to carbohydrates ingested as fruit and vegetables may vary depending on factors inherent to the fruit or vegetable, and on the type of sugar. The aim of this project is to investigate the glycaemic responses to two new fruit and vegetable smoothies, and to establish the glycaemic index for each product relative to a glucose reference. Participants will undertake 4 postprandial tests with 2 different test drinks following best practice guidelines for glycaemic index testing. The test drinks (GREEN and RED) will be matched for carbohydrate to the glucose reference (CONTROL) which will be sampled two times. Fingerstick capillary blood sampling will measure glucose concentrations. These data will provide insight into how differing formulations can alter the glycaemic responses to fruit and vegetable drinks.

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Key information

Conditions

Glycaemic Index Glycaemic Response Glycaemic Response Measurements

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department for Health, University of Bath

Bath, BA2 7AY, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 18-65 years
  • Body mass index 18-30 kg/m2

Exclusion criteria

  • diagnosis of any form of diabetes
  • intolerances or allergies to any of the study procedures (e.g. fructose/inulin intolerance)
  • Fructose malabsorption
  • Inborn errors of fructose metabolism (e.g. fructokinase deficiency, aldolase B deficiency, fructose-1,6-bisphosphatase deficiency)
  • pregnant or lactating
  • any condition that could introduce bias to the study (e.g. diagnoses of lipid disorders, including cardiovascular disease, or therapies that alter lipid or glucose metabolism, such as statins or niacin).

Treatment and study plan

Vegetable Smoothie

Other

Commercially available fruit and vegetable smoothie

Primary outcomes

  1. Glycaemic indices for 2 test drinks measured using capillary blood samples

    Time frame: 120 minutes

    Glycaemic indices [2-hour incremental area under the glucose curve (mmol/L-1x120 minutes) for each of the 2 test drinks relative to mean value of control conditions (CONTROL, REPLICATE CONTROL), expressed as a percentage] in capillary blood samples

Other outcomes

  1. Comparisons between conditions in glucose concentration in capillary samples

    Time frame: 120 minutes

    Comparison of blood glucose concentration 2-hour incremental area under the curve (iAUC) min.mmol/L between test conditions

  2. Comparisons between conditions in glucose concentration in capillary samples

    Time frame: 120 minutes

    Comparison of postprandial peak concentration mmol/L of blood glucose between test conditions (Cmax)

  3. Comparisons between conditions in glucose concentration in capillary samples

    Time frame: 120 minutes

    Comparison of time to peak blood glucose concentration in minutes (Tmax) between test conditions

  4. Comparisons between conditions in glucose concentration in capillary samples

    Time frame: 120 minutes

    Comparison of blood glucose concentration mmol/L at 2 hours between test conditions

Sponsors and collaborators

Lead sponsor

University of Bath

Other

Registry information

Official study title

Study to Establish Glycaemic Response to the Ingestion of Vegetable Smoothies Expressed as Glycaemic Index Following Best Practice Guidelines

Acronym: VEG-GI

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 27, 2026
Registry last updated
Jul 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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