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Clinical trial condition

Homozygous Familial Hypercholesterolemia

Explore clinical trials studying Homozygous Familial Hypercholesterolemia. Study availability and eligibility vary by location and protocol.

57 public trials 11 recruiting studies
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Homozygous Familial Hypercholesterolemia trial results

Recruiting

Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia

NCT06597006

Conditions
Aortic Valve Disease, Aortic Valve Stenosis, Cardiovascular Diseases, +18 more
Locations
  • UC San Francisco Medical Center San Francisco, California, United States
  • Childrens National Hospital Washington D.C., District of Columbia, United States
  • Washington Univ School Of Medicine St Louis, Missouri, United States
  • Primary Childrens Medical Center Salt Lake City, Utah, United States
View all 19 locations
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Recruiting

A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias

NCT07491172

Conditions
Cardiovascular, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyslipidemias, +20 more
Locations
  • Integrity Clinical Research Hialeah, Florida, United States
  • Jacksonville Center for Clinical Research Jacksonville, Florida, United States
  • Flourish Orlando Orlando, Florida, United States
  • United Medical Research Port Orange, Florida, United States
View all 19 locations
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Recruiting

A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)

NCT07037771

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyslipidemias, Genetic Diseases, Inborn, +9 more
Locations
  • Research Site 7 Park Ridge, Illinois, United States
  • Research Site 2 New York, United States
  • Research Site 1 Cincinnati, Ohio, United States
  • Research Site 14 Pittsburgh, Pennsylvania, United States
View all 43 locations
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Recruiting

Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies

NCT05682378

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyslipidemias, Genetic Diseases, Inborn, +10 more
Locations
  • Excel Medical Clinical Trials LLC Boca Raton, Florida, United States
  • Icahn School of Med at Mt Sinai New York, United States
  • Cincinnati Childrens Hospital MC Cincinnati, Ohio, United States
  • Childrens Hosp Pittsburgh UPMC Pittsburgh, Pennsylvania, United States
View all 52 locations
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Recruiting

Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Coronary Plaque Volumes Measured by Coronary Computed Tomography Angiography (CCTA) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)

NCT07447648

Conditions
Arterial Occlusive Diseases, Arteriosclerosis, Atherosclerosis, +16 more
Locations
  • Unité de Lipidologie et Prévention Cardiovasculaire, Centre de Compétence Dyslipidémies Rares (CEDRA), Service de Nutrition, Hôpital Pitié-Salpétriêre Paris, France
  • Dipartimento Scienze-Cardiovascolari, AO "Sant'Anna e San Sebastiano" di Caserta Caserta, Italy
  • U.O.C. di Medicina Interna, P.O. Nesima, ARNAS Garibaldi Catania, Italy
  • Nefrologia e Emodialisi, Centro Aterosclerosi e Dislipidemie, Ospedale Bassini, ASST Nord Milano Cinisello Balsamo, Italy
View all 13 locations
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Recruiting

The ORIGIN-FH Study

NCT07470723

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyslipidemias, Familial Hypercholesterolemia, +12 more
Locations
  • University of Wisconsin - Madison Madison, Wisconsin, United States
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Recruiting

HoFH, the International Clinical Collaborators Registry

NCT04815005

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Dyslipidemias, Genetic Diseases, Inborn, +12 more
Locations
  • University of Pennsylvania Philadelphia, Pennsylvania, United States
  • Department of Vascular Medicine, Amsterdam UMC Amsterdam, Netherlands
  • Department of Medicine, Division of Lipidology and Hatter Institute for Cardiovascular Research in Africa, University of Cape Town Cape Town, South Africa
  • c. Carbohydrate and Lipid Metabolism Research Unit, Faculty of Health Sciences, University of Witwatersrand Johannesburg, South Africa
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