Venous Thromboembolism in DM1

The risk for venous thromboembolism (VTE) in DM1 and in other inherited myopathies, which can lead to chronic immobilization, are unknown. The purpose of this study is to evaluate incidence of VTE in cohort of patients presenting with DM1 with a comparison to a group of other inheritable myopathies and to a community-based population.

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Key information

Conditions

Venous Thromboembolism Cardiovascular Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Deep Vein Thrombosis Embolism Embolism and Thrombosis Genetic Diseases, Inborn Heredodegenerative Disorders, Nervous System Lung Diseases Muscular Diseases Muscular Disorders, Atrophic Muscular Dystrophies Musculoskeletal Diseases Myopathy Myotonic Disorders Myotonic Dystrophy Myotonic Dystrophy 1 Nervous System Diseases Neurodegenerative Diseases Neuromuscular Diseases Pulmonary Embolism Respiratory Tract Diseases Thromboembolism Thrombosis Vascular Diseases Venous Thrombosis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

A cohort of more that 2,800 adult patients admitted to our Institutions between January 2000 and November 2014 with genetically proven myopathy will be retrospectively included.

Any information relative to their demographic and genetic characteristics, their muscular functional status and the occurrence of VTE will be collected.

Statistical analysis will be performed to estimate the incidence of venous thromboembolism in this population, to identify predictors of VTE, and to compare its incidence to a community-based population.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age > 18 years
Genetically proven myopathy
Admission in our institutions from January 2000 to November 2014

Exclusion criteria

Patient refusal

Treatment and study plan

Primary outcomes

Any episode of pulmonary embolism and/or deep vein thrombosis, diagnosed according to 2011 AHA guidelines on venous thromboembolism management

Time frame: 14 years

Sponsors and collaborators

Lead sponsor

Institut de Myologie, France

Other

Registry information

Official study title

Incidence and Predictors of Venous Thromboembolism in Myotonic Dystrophy

Acronym: DM1-VTE

Important dates

Study start: 2000
Primary completion: 2014
Study completion: 2017
First posted: May 5, 2017
Registry last updated: May 9, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed