Treatment of Survivors After Botulism Outbreak

Background. Northern Thailand's biggest botulism outbreak to date occurred on 14 March 2006 and affected 209 people. Of these, 42 developed respiratory failure, and 25 of those who developed respiratory failure were referred to 9 high facility hospitals for treatment of severe respiratory failure and autonomic nervous system involvement. Among these patients, we aimed to assess the relationship between the rate of ventilator dependence and the occurrence of treatment by day 4 versus day 6 after exposure to bamboo shoots (the source of the botulism outbreak), as well as the relationship between ventilator dependence and negative inspiratory pressure.

Methods. The investigators reviewed the circumstances and timing of symptoms following exposure. Mobile teams treated patients with botulinum antitoxin on day 4 or day 6 after exposure in Nan Hospital (Nan, Thailand). Eighteen patients (in 7 high facility hospitals) with severe respiratory failure received a low- and high-rate repetitive nerve stimulation test, and negative inspiratory pressure was measured.

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Key information

Conditions

Respiratory Failure Bacterial Infections Bacterial Infections and Mycoses Botulism Chemically-Induced Disorders Clostridium Infections Foodborne Diseases Gram-Positive Bacterial Infections Infections Nervous System Diseases Neuromuscular Diseases Neuromuscular Junction Diseases Neurotoxicity Syndromes Poisoning Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases

Age range

1 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Rajavithi Hospital

Bangkok, 10400, Thailand

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusions:

Ate the bamboo shoots in Banluang district, on March,14 2006
Clinical of respiratory failure and need ventilator assistant
Needed to referred to other hospital
The staffs of referred hospital willing to participate in the Thai Botulism study group

Exclusion criteria

Patients who did not eat bamboo shoots in Banluang district on March14,2006.
No clinical of respiratory failure.
Not referred to other hospital.

Treatment and study plan

Botulinum AntiToxin

Drug

neuro-electrophysiologic study, repetitive nerve stimulation

Procedure

Protocol early weaning ventilator after recovery of repetitive nerve stimulation and stable negative inspiratory pressure

Procedure

Sponsors and collaborators

Lead sponsor

Department of Medical Services Ministry of Public Health of Thailand

Other Gov

Collaborators

Rajavithi Biomolecular Research Center

Registry information

Official study title

An Outbreak of Botulism in Thailand: Clinical Manifestations and Management of Severe Respiratory Failure

Important dates

Study start: 2006
Study completion: 2006
First posted: Apr 12, 2006
Registry last updated: Oct 24, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed