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Completed

NCT Number: NCT07411976

Critical Care Admission Following Emergency Department's Resuscitation Room Care

This prospective multicenter observational study aims to describe resuscitation room activity in France and to compare critical care admission within 24 hours between patients directly admitted to the resuscitation room and those admitted secondarily after initial emergency department management. Adult patients admitted to the resuscitation room over a 72-hour period in participating centers will be included. Data collection includes patient characteristics, triage severity, physiological parameters, critical interventions, and outcomes at 24 hours.

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Key information

Conditions

Critical Illness Disease Attributes Emergencies Emergency Department Patient Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Failure Respiratory Insufficiency Respiratory Tract Diseases Resuscitation Shock Trauma (Including Fractures) Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Nîmes

Nîmes, 30029, France

About this study

This is a prospective, multicenter, observational cohort study including all consecutive adult patients admitted to the resuscitation room in participating emergency departments over a predefined 72-hour study period. Patients are categorized according to their mode of admission to the resuscitation room (direct or secondary after initial emergency department management). No intervention is assigned by the study, and patient care follows usual practice and local protocols. Data collection includes patient-level clinical and physiological variables, resuscitation room processes of care, organizational characteristics at the center level, and practitioner-level characteristics. The primary outcome is critical care admission or death within 24 hours after resuscitation room admission.

Statistical analysis Analyses will be conducted in adult patients (≥18 years) admitted to the resuscitation room. Patients will be categorized according to the mode of resuscitation room admission (direct vs secondary).

The primary outcome is critical care admission or death within 24 hours after resuscitation room admission. The primary analysis will compare the proportion of patients meeting the primary outcome between groups using logistic regression, with adjustment for prespecified baseline variables and center effects. Results will be reported as odds ratios with 95% confidence intervals. Secondary and prespecified outcomes will be analyzed descriptively. Missing data will be described and analyses performed on available data.

An ancillary analysis will be conducted among patients who receive blood transfusion during resuscitation room management. This ancillary study will use the same prospective observational dataset and will not involve any additional data collection or modification of patient management. Analyses will focus on patient characteristics, indications for transfusion, transfusion practices, and short-term outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients (≥18 years old) admitted to the resuscitation room during the study period.

Exclusion criteria

  • Patients younger than 18 years.

Treatment and study plan

Emergency resuscitation room management (observational)

Other

Patients receive standard emergency care in the resuscitation room according to local protocols and clinician judgment. No intervention is assigned by the study. Clinical management, diagnostic procedures, and therapeutic interventions are recorded for observational purposes only.

Primary outcomes

  1. Critical care admission within 24 hours after resuscitation room admission

    Time frame: Within 24 hours after resuscitation room admission

    Proportion of patients admitted to critical care (intensive care unit or intermediate care unit) or deceased within 24 hours following admission to the resuscitation room, comparing direct versus secondary resuscitation room admission.

Secondary outcomes

  1. All-cause mortality within 24 hours

    Time frame: Within 24 hours after resuscitation room admission

    All-cause mortality occurring within 24 hours after resuscitation room admission.

  2. Use of critical care interventions in the resuscitation room

    Time frame: Day 1

    Proportion of patients receiving at least one critical care intervention in the resuscitation room, including airway management, mechanical ventilation or non-invasive ventilation, vasopressor therapy, transfusion, renal replacement therapy, or cardiopulmonary resuscitation.

  3. Center-level organizational characteristics

    Time frame: Baseline (during study period)

    Description of resuscitation room organizational characteristics, including material resources, human resources, and availability of critical care equipment.

  4. Physiological severity at resuscitation room admission-part 1

    Time frame: Baseline

    Blood pressure at admission

  5. Physiological severity at resuscitation room admission-part 2

    Time frame: Baseline

    Heart rate at admission

  6. Physiological severity at resuscitation room admission-part 3

    Time frame: Baseline

    Respiratory rate at admission

  7. Physiological severity at resuscitation room admission-part 4

    Time frame: Baseline

    Pulsed oxygen saturation at admission

  8. Physiological severity at resuscitation room admission-part 5

    Time frame: Baseline

    Temperature at admission

  9. Physiological severity at resuscitation room admission-part 6

    Time frame: Baseline

    Glasgow Coma Scale at admission

  10. Physiological severity at resuscitation room admission-part 7

    Time frame: Baseline

    Capillary blood glucose at admission

  11. Physiological severity at resuscitation room admission-part 8

    Time frame: Baseline

    Capillary blood glucose at admission

Other outcomes

  1. Time from emergency department arrival to resuscitation room admission

    Time frame: Day 1

    Time interval between emergency department arrival and resuscitation room admission

  2. Blood transfusion during resuscitation room management

    Time frame: Day 1

    Proportion of patients receiving at least one blood product transfusion during resuscitation room management.

  3. Specialist consultation in the resuscitation room

    Time frame: Day 1

    Proportion of patients requiring at least one specialist consultation during resuscitation room management.

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nīmes

Other

Collaborators

  • Societe Française de Medecine d'urgence

Registry information

Official study title

SAUV IRU: A Multicenter Prospective Observational Study Describing Resuscitation Room Activity and Comparing Critical Care Admission After Direct vs Secondary Admission

Acronym: SAUV-IRU

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 17, 2026
Registry last updated
Jun 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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