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NCT Number: NCT05604339

Study of Recovery and Blood Rheology Changes in Ultra-endurance Runners (ERUPTION-3)

While the acute consequences of an ultratrail are beginning to be well documented, data on the study of recovery in the aftermath of an event are much rarer.

In order to overcome these various limitations, the main study of the ERUPTION-3 project is set up on the Grand Raid de La Réunion 2022 races.

In the context of exercise responses, the rheological properties of blood can impact the endurance performance. In contrast to short-distance events, the study of blood rheology and red blood cells integrity in long-distance events such as ultra-endurance races is poorly documented in the literature.

In the ancillary study, the work that is intended to be carried y out will complement the initial results found by a previous research on 23 runners during the Ultra Trail du Mont Blanc. This ancillary study will also be an opportunity to complete the data from the main study by studying the kinetics of biomarker recovery.

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Key information

Conditions

Physiology

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de la Réunion

Saint-Denis, 97400, Reunion

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • >18 years
  • Participating in the Grand Raid de la Réunion race (Mascareignes, Trail de Bourbon or Diagonale des fous)
  • Affiliated or beneficiary of a social security scheme
  • Not opposed to the research for the main study
  • Having given their written consent for the participants of the ancillary study

Exclusion criteria

  • Not understanding French
  • Protected adult (guardianship or curatorship) or under court protection
  • Who have difficulty swallowing paracetamol capsules and for whom it will therefore be difficult to swallow the e-Celsius® Performance capsules (for the ancillary study)

Treatment and study plan

Primary outcomes

  1. Recovery and its kinetics in the aftermath of an ultratrail run in a tropical environment.

    Time frame: 3 Months

    Evaluate by means of subjective evaluations in the aftermath of an ultratrail run in a tropical environment:

    • Hooper Index (4 questions: sleep, stress, tiredness and muscular pain) each ranging from 1 to 7 with 1 being very good ranking and 7 worse ranking

  2. Recovery and its kinetics in the musculo-articular evaluations in the aftermath of an ultratrail run in a tropical environment.

    Time frame: 3 Months

    Evaluate by means of subjective evaluations in the aftermath of an ultratrail run in a tropical environment:

    • musculo-articular recovery (descriptive assessment no score)

  3. Recovery and its kinetics of sleep in the aftermath of an ultratrail run in a tropical environment.

    Time frame: 3 Months

    Evaluate by means of subjective evaluations in the aftermath of an ultratrail run in a tropical environment:

    • sleep questionnaire (descriptive assessment no score)

  4. Recovery and its kinetics of tiredness in the aftermath of an ultratrail run in a tropical environment.

    Time frame: 3 Months

    Evaluate by means of subjective evaluations in the aftermath of an ultratrail run in a tropical environment:

    • tiredness questionnaire (descriptive assessment no score)

  5. Recovery and its kinetics of injury in the aftermath of an ultratrail run in a tropical environment.

    Time frame: 6 Months

    Evaluate by means of subjective evaluations in the aftermath of an ultratrail run in a tropical environment:

    • injury questionnaire (descriptive assessment no score)

  6. To evaluate recovery and its kinetics in its different dimensions in ultra-endurance runners

    Time frame: 1 Month

    Evaluate by means of objective evaluations in the aftermath of an ultratrail run in a tropical environment:

    1200m and 400m test (best race time)

  7. Ancillary Study: Change in Hematological Recovery biomarkers

    Time frame: Day 2, Day 5, Day 9 and Day 16

    Evaluate the changes in recovery kinetics of biological markers (hematological:haemoglobin in g/dL ) directly after the race in comparison with measurements taken before the race

  8. Ancillary Study: Change in Muscular Recovery biomarkers

    Time frame: Day 2, Day 5, Day 9 and Day 16

    Evaluate the changes in recovery kinetics of biological markers (muscular: Creatin PhosphoKinase in UI/L), directly after the race in comparison with measurements taken before the race

  9. Ancillary Study: Change in Inflammatory Recovery biomarkers

    Time frame: Day 2, Day 5, Day 9 and Day 16

    Evaluate the changes in recovery kinetics of biological markers (inflammatory: Protein C-reactive in mg/L) directly after the race in comparison with measurements taken before the race

  10. Ancillary Study: Change in Hepatic Recovery biomarkers

    Time frame: Day 2, Day 5, Day 9 and Day 16

    Evaluate the changes in recovery kinetics of biological markers (hepatic: ASAT & ALAT in UI/L) directly after the race in comparison with measurements taken before the race

  11. Ancillary Study: Blood rheologic properties and the senescence of red blood cells

    Time frame: Post-race (between day2 and day4 depending on the time of race arrival)

    Evaluate the rheologic biomarkers by measuring the blood viscosity directly after the race in comparison with measurements taken before the race

  12. Ancillary Study: Senescence of red blood cells

    Time frame: Post-race (between day2 and day4 depending on the time of race arrival)

    Evaluate the Senescence of red blood cells directly after the race in comparison to before the race, by taking blood samples and analysing them using spectrophotometry and fluorescent-activated cells sorting

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de la Réunion

Other

Collaborators

  • Aspetar Orthopedic and Sports Medicine Hospital
  • Jean Monnet University
  • Universite de La Reunion

Registry information

Official study title

Etude de la récupération et Des Modifications de la rhéologie Sanguine Chez Les Coureurs d'Ultraendurance ERUPTION-3 / Study of Recovery and Blood Rheology Changes in Ultra-endurance Runners ERUPTION-3

Acronym: ERUPTION-3

Important dates

Study start
2022
Primary completion
2022
Study completion
2023
First posted
Nov 3, 2022
Registry last updated
Aug 14, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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