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OpenTrials
Completed

NCT Number: NCT02850367

Effect of NO Precursors on Physiological Responses to Exercise

NO is an ubiquitous molecule contributing to many physiological functions such as vasodilation, immune and oxidative stress responses. NO production can be supplemented either by providing substrate to the NO-synthase (L-Arginine and L-Citruline) or by providing nitrate which can lead to NO. In the present project the investigators evaluate the effect of various acute and chronic oral NO precursors supplementation on exercise performance and responses in healthy young and older subjects.

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Key information

Conditions

Physiology

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Grenoble University Hospital

Grenoble, Auvergne-Rhône-Alpes, 38043, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Sedentary subjects
  • No cardiovascular, respiratory, metabolic and neurological disorders

Exclusion criteria

  • Body mass index > 28 kg.m-2
  • Smoker
  • Alcool intake > 10g/day
  • Psychiatric diseases
  • Subjects under treatment able to interfere with their cardiovascular, metabolic and neurological status

Treatment and study plan

Nitrate

Dietary Supplement

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

Nitrate and L-Arginine

Dietary Supplement

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

Nitrate and L-Citrulline

Dietary Supplement

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

Placebo

Dietary Supplement

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with a placebo.

Evaluation of post-ischemic vascular reactivity

Biological

After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS.

Neuromuscular evaluations

Biological

After the intake of the supplement. Measure the stretching force in the ankle (N)

Primary outcomes

  1. Neuromuscular evaluations

    Time frame: 3 half days

    After the intake of the supplement. Measure the stretching force in the ankle (N)

  2. Evaluation of post-ischemic vascular reactivity

    Time frame: 3 half days

    After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS.

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Registry information

Official study title

The Effect of NO Precursors on Physiological Responses to Exercise

Acronym: NO-SUP

Important dates

Study start
2016
Primary completion
2021
Study completion
2021
First posted
Aug 1, 2016
Registry last updated
Dec 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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