Influence of Sleep Regularity on Circadian Rhythms, Learning, Performance, and Mood

The study is a combination of outpatient and inpatient monitoring. During the 27-day inpatient portion of the study, the individual's sleep-wake schedule will be varied daily. Volunteers will be randomized to a regular or irregular inpatient schedule.

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Key information

Conditions

Physiology

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

healthy
BMI between 18.5 and 29.5

Exclusion criteria

medications
recent night-work, shift-work, or travel across >2 time zones
use of medications
pregnant or within 6 months post-partum

Treatment and study plan

Sleep/Wake Schedule

Other

Timing of sleep and wake

Primary outcomes

Circadian phase

Time frame: 27 days

Circadian phase, as measured by melatonin, at end vs. beginning of inpatient portion of experiment
Learning

Time frame: 27 days

Sleep-dependent learning at 3-4 times during inpatient portion of the experiment
Mood

Time frame: 27 days

Mood (using a linear non-numeric scale) across difference days inpatient portion of the experiment

Sponsors and collaborators

Lead sponsor

Brigham and Women's Hospital

Other

Registry information

Important dates

Study start: 2016
Primary completion: 2021
Study completion: 2025
First posted: Jul 20, 2016
Registry last updated: Jan 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed