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NCT Number: NCT07465380

Stabilization vs Corrective Exercise in PFP

The purpose of this study is to investigate the effects of a Functional Stabilization training program (FST) and a comprehensive corrective exercise program in PF pain and DKV.

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Key information

Conditions

Patellofemoral Pain Syndrome Bone Diseases Genu Valgum Joint Diseases Musculoskeletal Diseases

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

PF pain impairs performance and quality of life and can predispose individuals to early PF osteoarthritis and Dynamic knee valgus has been identified as a modifiable risk factor for PF pain and serious knee injury .

Current rehabilitation strategies show mixed results. Solo hip strengthening programs may not correct Dynamic knee valgus. While both Functional Stabilization training (FST) and comprehensive corrective programs (CCEP) show potential benefits, direct comparisons are lacking. The FST suggested superior outcomes with functional training, but it did not specifically target DKV. Conversely, the CCEP demonstrated kinematic improvements, but included asymptomatic participants and lacked patient reported outcomes.

By directly comparing Functional Stabilization training (FST) with the CCEP, this study aims to provide clinicians with evidence based guidance on the most effective exercise strategy for improving lower limb kinematics and reducing pain. The findings could inform best practice guidelines and enhance outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patellofemoral pain lasting > 6 weeks
  • Demonstrates dynamic knee valgus during single-leg squat (FPPA ≥ 10°).
  • Arabic Kujala Patellofemoral Scale (KPS) score < 80.
  • Age 18-35 years

Exclusion criteria

  • Previous knee surgery; ligament/meniscus injury; or lower-limb fractures
  • Neurologic disorders.
  • Systemic inflammatory disease
  • Pregnancy.

Treatment and study plan

Standard Care Exercise Program (SC)

Behavioral

Supervised standard care exercise therapy for patellofemoral pain, delivered 3 sessions/week for 8 weeks (24 sessions), ~45-60 minutes/session.

Functional Stabilization Training (FST)

Behavioral

Supervised functional stabilization/neuromuscular exercise program focusing on lower-limb alignment and movement control. 3 sessions/week for 8 weeks (24 sessions), ~45-60 minutes/session, progressive difficulty/load

Other names: Neuromuscular training

Comprehensive Corrective Exercise Program (CCEP)

Behavioral

Supervised comprehensive corrective exercise program targeting flexibility, strength, and neuromuscular control across the kinetic chain to address dynamic knee valgus. 3 sessions/week for 8 weeks (24 sessions), ~45-60 minutes/session, phase-based progression

Primary outcomes

  1. Peak Knee Abduction (Valgus) Angle (3D motion analysis)

    Time frame: Baseline and 8 weeks

    Change in peak knee abduction (valgus) angle of the stance limb measured using a 3D motion capture system (Vicon) during functional tasks (single-leg squat and drop/vertical jump landing). Lower values indicate reduced dynamic knee valgus.

  2. Hip and Pelvis Kinematics (3D motion analysis)

    Time frame: Baseline and 8 weeks

    Change in peak hip adduction, peak hip internal rotation, contralateral pelvic drop, and trunk lateral lean during the functional tasks measured by 3D motion capture.

Secondary outcomes

  1. Kujala Patellofemoral Scale (KPS)

    Time frame: Baseline and 8 weeks

    Change in patient-reported knee function using the Arabic Kujala Patellofemoral Scale (0-100)

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed Alshab, PhD Cand

CONTACT

[email protected]

+201008816911

Enas Fawzy, PhD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Ahram Canadian University

Other

Registry information

Official study title

Functional Stabilization Training VS Comprehensive Corrective Exercises on Lower Limb Kinematics in Patellofemoral Pain and Dynamic Knee Valgus

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Mar 11, 2026
Registry last updated
Mar 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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