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NCT Number: NCT07664566

Core Stability Exercises Versus Proprioceptive Training on Pain and Function in Patients With Patellofemoral Pain Syndrome

This study will be conducted to investigate the effect of core stability exercises versus proprioceptive training in patients with patellofemoral pain syndrome.

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Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Patellofemoral Pain Syndrome (PFPS) is one of the most prevalent musculoskeletal disorders causing anterior knee pain, particularly during activities that increase patellofemoral joint stress such as squatting, stair climbing, running, or prolonged sitting .Core stability exercises play a fundamental role in maintaining the kinetic chain alignment between the trunk, pelvis, and lower limb. Dysfunction of the lumbopelvic-hip complex can lead to compensatory movement patterns, increasing stress on the knee joint. Strengthening the core muscles, particularly the transversus abdominis, multifidus, and gluteal muscles, enhances postural control and optimizes force transmission during dynamic activities. Proprioceptive training, on the other hand, targets sensorimotor control by enhancing afferent feedback and neuromuscular coordination. Individuals with PFPS often present with impaired joint position sense and delayed neuromuscular responses around the knee, which may contribute to joint instability and persistent pain. Proprioceptive exercises, including balance, perturbation, and kinesthetic training, improve joint stability and coordination by stimulating mechanoreceptors and enhancing central processing of sensory input.Therefore, this study will aim to fill an important gap in the current literature by directly comparing the effects of core stabilization exercises and proprioceptive training on pain intensity, pain pressure threshold, quadriceps muscle strength, and proprioceptive acuity of knee, knee joint range of motion and functional ability in patients with PFPS

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • A confirmed diagnosis of Patellofemoral Pain Syndrome (PFPS) based on clinical and radiographic examination, with no evidence of other knee pathologies, as verified by an orthopaedic physician
  • Presence of unilateral PFPS for a minimum duration of three months, indicating a chronic condition
  • Age between 18 and 40 years, representing the typical symptomatic population affected by PFPS
  • Body Mass Index (BMI) less than 30 kg/m², ensuring exclusion of obesity as a confounding factor.
  • Report of increased anterior knee pain during at least two of the following patellofemoral stress-provoking activities: stair ascent or descent, squatting, kneeling, running, or prolonged sitting
  • A positive patellar grind test (Clarke's sign) confirming involvement of the patellofemoral joint

Exclusion criteria

  • Presence of chronic pain conditions unrelated to Patellofemoral Pain Syndrome (PFPS) as Rheumatoid arthritis, Chronic neuropathic pain, chronic low back pain and knee and hip osteoarthritis.
  • Pregnancy or history of recent trauma affecting the pelvic or knee region
  • History of corticosteroid injection in the affected knee
  • Presence of ankle arthritis or gouty arthritis, which may alter lower-limb biomechanics
  • History of previous surgical intervention involving the lumbar spine, hip, knee, or foot
  • Presence of lower-limb structural deformities, including pes planus, knee valgus, or knee varus deformities

Treatment and study plan

Core Stability Exercises

Other

core stability exercises including warm-up, main training, and cool-down phases; warm up exercises in the form of Cat-Camel exercise will be performed for 5-8 cycles to mobilize the spine and promote smooth segmental motion. The primary main training consisted of McGill's "Big Three" core stabilization exercises, which emphasize endurance and control of the deep stabilizing muscles, curl up, side bridge, and Quadrupedal stance, finallly the cool down phase had dynamic stretching at the end of each session to reduce muscle tension and promote recovery plus tradional therapy

Proprioceptive training

Other

proprioceptive training consisted of group of exercises for balance on 1 leg on a stable surface and a unstable surface. in addition to tradional therapy.

traditional therapy

Other

tradional therapy in the form of interferential therapy, knee strengthening exercises, knee strengthening exercises, stretching exercises, patellar mobilization and ischemic compression

Primary outcomes

  1. pain intensity

    Time frame: up to four weeks

    pain will be assessed by VAS which line on a 100 mm , where 0 indicates no pain and 100 indicates the worst possible pain.

  2. knee disability

    Time frame: up to four weeks

    knee disability will be assessed by Kujala Patellofemoral Questionnaire.Which is a 13-item questionnaire including different items on pain related to functioning and activities. The categories within each item are weighted and item scores summed to provide an overall index scored from 0 to 100, where the maximum score of 100 represents no disability.

Secondary outcomes

  1. pressure pain threshold

    Time frame: up to four weeks

    The pressure algometer will be used to assess pressure pain threshold

  2. knee range of motion

    Time frame: up to four weeks

    The electro goniometer will be used to assess knee range of motion.

  3. knee proprioception (joint position error)

    Time frame: up to four weeks

    proprioception will beassesseds by electrogoniometer. The participant's knee will be passively positioned at a target angle (e.g., 30° flexion) then returned to the starting position, then the patient will be asked to actively reproduce the target angle.The absolute angular error (degrees) between the target and reproduced angles will be recorded.

  4. quadriceps muscle strength

    Time frame: up to four weeks

    Quadriceps muscle strength will be measured by a handheld dynamometer.

Study contacts

Contact information is provided by the study sponsor or research team.

mohamed hassan, phd

CONTACT

[email protected]

0 11 21363081

mohamed hassan, phd

CONTACT

[email protected]

01121363081

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Acronym: PFPS

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jun 24, 2026
Registry last updated
Jun 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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