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NCT Number: NCT07698704

Popliteus Muscle Release Versus Patellofemoral Mobilization in Patellofemoral Pain Syndrome

This study will be conducted to compare the effect of popliteus muscle release and patellofemoral mobilization on pain intensity, function, and quadriceps muscle strength in patients with patellofemoral pain syndrome?

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Key information

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

The gradual development of diffuse anterior knee pain is characteristic of patellofemoral pain (PFP), which is made worse by activities that put stress on the patellofemoral joint, such as running, stair climbing, and squatting. While 23% of the overall population has PFP, athletes can have a prevalence of 35%.Patellofemoral pain syndrome (PFPS) is a widespread disease with a significant impact on society, with a 22.7% prevalence in the general population.The patella is the largest sesamoid bone in the body and acts as a fulcrum to improve the mechanical advantage of the quadriceps. In full knee extension the patella does not articulate with the femoral condyles, and related to the lack of articular congruency, is able to glide more freely. The inferior patellar facet first contacts the femoral condyle around 20-30o of knee flexion.The popliteus tendon is a primary stabilizer of external knee rotation and has been described as the "fifth ligament of the knee." Injuries involving the posterolateral corner of the knee commonly involve the popliteus tendon; isolated injury to the popliteus tendon is relatively rare and usually involves a rotatory injury mechanism and symptoms of instability and pain.Myofascial release has been shown to improve pain, range of motion, and functional outcomes in individuals with knee disorders. By targeting fascial restrictions around the quadriceps, hamstrings, iliotibial band, and peri-patellar tissues, myofascial techniques help reduce tissue stiffness and abnormal tension that may contribute to altered patellar tracking and joint loading.Patellofemoral mobilization is considered an important intervention in the management of PFPS, particularly in patients presenting with pain, stiffness, or altered patellar tracking.Although both techniques are used to reduce anterior knee pain and improve function, current evidence is insufficient to determine which intervention is more effective. Therefore, further randomized controlled trials are needed to compare their effects on pain and functional outcomes in individuals with PFPS.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female participants aged 18-30 years.
  • minimum history of 3 months of unilateral PFP.
  • pain intensity score of ≥3 on a 10-cm Visual Analog Scale (VAS) for worst pain experienced during the previous week.
  • Pain reproduced during at least two of the following functional activities: stair ascent or descent, running, hopping, prolonged sitting, squatting, or kneeling.
  • Presence of pain on at least one of the following clinical tests: patellar compression test or palpation of the patellar facets.

Exclusion criteria

  • Clinical, x-ray, or MRI findings indicative of other specific pathology including osteoarthritis, meniscal, ligament or cartilage injury, apophysitis.
  • Recurrent patellar subluxation or dislocation.
  • Cortisone use over an extended period of time.
  • Previous surgery to the knee joint; trauma to the knee joint affecting the presenting clinical condition.
  • Lower limb deformities.

Treatment and study plan

Popliteus Muscle Release

Other

the participant will lie supine and relaxed on a treatment bench. The therapist will begin the treatment by flexing the participant's knee to approximately 15-25 degrees. Then, the therapist will apply pressure to the popliteus muscle while simultaneously extending the knee to approximately 5 degrees of flexion. When the knee is extended, the pressure will be released. The therapist will repeat this procedure for up to 2 minutes plus tradional therapy

Patellofemoral Mobilization

Other

Following the clinical guidelines established by Brukner and Khan, the mobilization will be performed with the patient in a supine position to ensure complete relaxation of the quadriceps musculature, thereby minimizing joint compressive forces. The intervention will include multidirectional glides tailored to specific functional deficits:Superior glides,Inferior glides,Medial-lateral excursions and tilt mobilization.Each mobilization will be applied as a gentle sustained glide for duration of 30 to 60 seconds per repetition

traditional therapy

Other

patients will receive quadriceps muscle strength, hip extension strength, hamstring stretch.

Primary outcomes

  1. pain intensity

    Time frame: up to four weeks

    The scale used will be the visual analogue scale (VAS), which consists of a line, usually 10 cm long, the patient will be instructed to place a vertical mark on to indicate his/ her pain, ranging from no pain or discomfort (0), to the worst pain that could possibly feel

Secondary outcomes

  1. knee disability

    Time frame: up to four weeks

    The Kujala Arabic version will be used to assess knee disability. it is 13 items on the scale are used to assess subjective symptoms and functional restrictions. A score can have a minimum of 0 points or a maximum of 100 points.Lower scores reflect greater pain and disability

  2. quadriceps muscle strength

    Time frame: up to four weeks

    A handheld dynamometer will be used to assess quadrecips muscle strength

Study contacts

Contact information is provided by the study sponsor or research team.

mohamed Bahig, master

CONTACT

[email protected]

0 11 41644884

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Acronym: PFPS

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 13, 2026
Registry last updated
Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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