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NCT Number: NCT07703072

Effect of Short Foot Exercise Combined With Focused Hip and Knee Exercises on Pain, Q Angle and Functional Outcomes in Female Patients With Patellofemoral Pain Syndrome

This randomized controlled trial aims to evaluate the effectiveness of short foot exercises combined with focused hip and knee strengthening on pain, Q-angle, and functional outcomes in female patients with patellofemoral pain syndrome (PFPS). Thirty-eight participants aged 18-45 years will be randomly assigned to either an experimental group (short foot + hip and knee exercises) or a control group (hip and knee exercises only) for a 6-week supervised rehabilitation program.

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Key information

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Patellofemoral Pain Syndrome (PFPS) is a common musculoskeletal condition characterized by anterior knee pain, particularly prevalent among females due to anatomical and biomechanical factors. Although conventional rehabilitation focuses on hip and quadriceps strengthening, persistent symptoms suggest the involvement of distal biomechanical contributors such as foot pronation and intrinsic foot muscle weakness.

Short Foot Exercise (SFE) targets intrinsic foot musculature, improves medial longitudinal arch stability, and enhances neuromuscular control. This study investigates whether combining SFE with hip and knee strengthening provides superior outcomes compared to conventional rehabilitation alone.

This study is a two-arm parallel randomized controlled trial including 38 female participants aged 18-45 years diagnosed with PFPS. Participants will be randomly allocated into experimental and control groups using a computer-generated sequence with allocation concealment. The intervention will be conducted over 6 weeks, with three supervised sessions per week.

The experimental group will receive short foot exercises along with hip and knee strengthening, while the control group will receive hip and knee strengthening only. Outcome measures including pain (VAS), functional status (Kujala AKPS), and Q-angle will be assessed at baseline and post-intervention.

The study aims to determine whether a combined proximal-distal rehabilitation approach leads to better improvements in pain, alignment, and functional outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosed cases of patellofemoral pain syndrome confirmed by this protocol.

  • Females aged 18-45 years
  • Anterior or retro patellar knee pain lasting ≥ 6 weeks
  • Pain provoked by at least one PFJ-loading task, including:
  • squatting,
  • stair climbing/descending,
  • running,
  • prolonged sitting with knees flexed
  • Pain elicited by at least two of four clinical tests;
  • Pain during isometric quadriceps contraction at 20-30° knee flexion
  • Pain on palpation of the patellofemoral joint line
  • Pain during patellar compression
  • Pain during active resisted knee extension

Exclusion criteria

History of patellar instability, including subluxation or dislocation 2. Evidence of tibiofemoral pathology, such as: Ligamentous injuries, meniscal tears, and symptomatic knee effusion.

  • Previous knee surgery within the last 12 months 4. Radiographic or clinical knee osteoarthritis. 5. Neurological disorders or systemic inflammatory diseases that may influence gait or pain perception.

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Treatment and study plan

Short foot exercise + Hip and Knee Strengthening exercise

Other

Short Foot Exercises (SFE) Structured intrinsic foot muscle training involving medial longitudinal arch elevation without toe flexion, progressing from seated to standing and functional positions.

Hip and Knee Strengthening Exercises Progressive strengthening program targeting hip abductors, external rotators, and quadriceps muscles through functional and resistance-based exercises.

Hip and Knee Strengthening Exercises

Other

Hip and Knee Strengthening Exercises alone Progressive strengthening program focusing on hip abductors, external rotators, and quadriceps muscles, including both non-weight-bearing and functional weight-bearing exercises.

Primary outcomes

  1. Kujala Anterior knee pain scale (AKPS)

    Time frame: Baseline measurement and after 6 weeks intervention

    The Kujala AKPS is a 13-item questionnaire specifically designed to evaluate symptoms and functional limitations associated with patellofemoral disorders. It assesses domains such as limping, walking, running, stair climbing, squatting, sitting, swelling, and pain. Total scores range from 0 to 100. Scores ranging 90-100 indicating better knee function while score range from 0-50 shows significant pain and functional impairment.

  2. Visual Analogue Scale

    Time frame: Baseline measurement and after 6 weeks intervention

    The Visual Analogue Scale is a 10-cm line used to assess the intensity of pain. Participants mark a point on the line that represents their current level of pain, ranging from 0 = no pain to 10 = worst possible pain. The distance in centimeters is measured to quantify pain severity.

Secondary outcomes

  1. Q angle

    Time frame: Baseline measurement and after 6 weeks intervention

    The Q-angle represents the quadriceps pull angle, measured using a universal goniometer by aligning landmarks at the anterior superior iliac spine (ASIS), center of patella, and tibial tuberosity. Patient lies in a supine relaxed position with knee extended. Fulcrum of goniometer is placed directly over the center of patella and stationary arm is aligned with the line connecting ASIS to midpoint of patella while the moving arm is aligned with the line connecting tibial tuberosity to the midpoint of patella. It provides insight into lower-limb alignment and patellar tracking mechanics. Normal Q angle measurement in females ranges from 13-19 degrees. Altered or increased Q-angles have been associated with PFPS and patellar maltracking.

Study contacts

Contact information is provided by the study sponsor or research team.

Afifa Khizar, MSPT

CONTACT

[email protected]

+923359077922

Aroona Sattar

CONTACT

[email protected]

+923054630138

Sponsors and collaborators

Lead sponsor

Lahore University of Biological and Applied Sciences

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 14, 2026
Registry last updated
Jul 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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