Smoking and Peptidoglycan Recognition Protein-1 and Initial Periodontal Therapy

A total of 40 patients with CP (20 smokers (S+CP) and 20 nonsmokers (S-CP)) and 40 periodontally healthy subjects (20 smokers (S+PH) and 20 nonsmokers (S-PH)), comprising 80 subjects, were included in this study. Baseline GCF samples were obtained from all subjects and clinical periodontal measurements, including probing depth (PD), clinical attachment level (CAL), plaque index (PI), and gingival index (GI), were recorded. In patients who had received initial periodontal therapy, GCF samples were obtained and all clinical periodontal measurements were recorded again during the 6th-8th weeks. GCF PGRP-1 levels were analyzed by enzyme-linked immunosorbent assay.

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Key information

Conditions

Smoking, Cigarette Behavior Chronic Disease Chronic Periodontitis Cigarette Smoking Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Smoking Stomatognathic Diseases Tobacco Smoking Tobacco Use

Age range

22 year–56 year

Study type

Interventional

Phase

Not applicable

About this study

Peptidoglycan recognition proteins (PGRPs) are one of the antimicrobial peptides that play a role in innate immunity and act against the bacterial cell wall. Smoking is the most important environmental risk factor for periodontitis. This study determined the effect of smoking on PGRP-1 levels in gingival crevicular fluid (GCF) in smokers and nonsmokers with chronic periodontitis (CP) following initial periodontal therapy.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical diagnosis of severe chronic periodontitis
Clinical diagnosis of periodontal health

Exclusion criteria

have any systemic disease,
to be alcohol consumer,
to receive any periodontal therapy in the past 6 months,
to take any drugs regularly
to be pregnant and/or lactate.

Treatment and study plan

Initial periodontal therapy

Other

Scaling and root planing and polishing with specific curettes were performed to patients with CP and oral hygiene education was provided to each patient.

Primary outcomes

Change in peptidoglycan recognition protein-1

Time frame: Baseline and 3 months

Total amount of Peptidoglycan Recognition Protein-1 (µg) in gingival crevicular fluid

Secondary outcomes

Change in periodontal clinical parameter

Time frame: Baseline and 3 months

Clinical attachment level (mm) (from cemento-enamel junction to the base of periodontal pocket)

Sponsors and collaborators

Lead sponsor

Kırıkkale University

Other

Registry information

Official study title

The Effect of Smoking on Gingival Crevicular Fluid Peptidoglycan Recognition Protein-1 Level Following Initial Periodontal Therapy in Chronic Periodontitis

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Apr 16, 2019
Registry last updated: Apr 16, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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