Addictive Potential of LCCs in Dual Users

This study is about whether or not little cigars and cigarillos cause or maintain addiction, and if flavors, such as fruit, make them more addictive. The purpose of this study is to understand the addiction potential of little cigars and cigarillos compared to cigarettes in young adults who smoke both products. This study will also look at the differences between men and women. In the rest of this form, little cigars or cigarillos will be referred to as LCCs.

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Key information

Conditions

Tobacco Use Disorder Behavior Chemically-Induced Disorders Cigar Smoking Cigarette Smoking Dual Tobacco Use Mental Disorders Smoking Smoking, Cigar Smoking, Cigarette Smoking, Tobacco Substance-Related Disorders Tobacco Dependence Tobacco Smoking Tobacco Use

Age range

18 year–34 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UConn Health

Farmington, Connecticut, 06030, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Current regular dual user of little cigars/cigarillos (LCCs) and cigarettes, defined as: (a) report smoking cigarettes on ≥ 8 of the past 30 days, and (b) report smoking unaltered LCCs (without marijuana) on ≥ 8 of the past 30 days.
Able to speak, read and understand English
Age 18-34 years of age
Stable residence (not planning to move during study period)
Not intending to quit smoking cigarettes or LCCs within the next 2 weeks
An expired carbon monoxide (CO) level of at least 4 ppm of expired air to verify smoking status

Exclusion criteria

Pregnant for women (verified by urine pregnancy test at Visits 1 and 2)
Current use of (or plans to use in the next 2-3 weeks) nicotine replacement products or cessation products (e.g., bupropion) to minimize confounding effects of another product)
Positive breath alcohol screen (breath alcohol level (BAL) > 0 g/ml; one re-test allowed; assessed at Visits 1, 2, and 3)
Illicit drug use other than marijuana (verified by positive drug toxicology test at Visits 1 and 3; one re-test allowed)
Met criteria for Cannabis Dependence assessed by the Cannabis Use Disorders Identification Test-Revised (CUDIT-R)

Treatment and study plan

Flavored and unflavored little cigars/cigarillos (LCCs)

Other

Flavored and unflavored LCCs that are currently available for purchase

Primary outcomes

Demand Elasticity

Time frame: Post-treatment (after being assigned to use it for 7 days)

Hypothetical consumption of LCCs as prices increase. These are the model-adjusted predicted mean values of elasticity, adjusted for covariates. It is the expected change in consumption for a one unit change in price.
Demand Intensity

Time frame: Post-treatment (after 7 days of being assigned to condition)

Hypothetical consumption when free. These are the model-adjusted predicted mean values of intensity, adjusted for covariates.

Sponsors and collaborators

Lead sponsor

UConn Health

Other

Registry information

Official study title

Addictive Potential of Little Cigars/Cigarillos in Dual Users: Effect by Flavor and Gender

Important dates

Study start: 2018
Primary completion: 2020
Study completion: 2020
First posted: Apr 12, 2018
Registry last updated: Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed