GCF IL-17 Levels and Oxidative Status of Smoking and Non-smoking Individuals With Periodontitis

This study was performed to evaluate the effects of both periodontal treatment and smoking on the gingival crevicular fluid(GCF) levels of interleukin (IL)-17A, IL-17E, Total oxidative stress(TOS) and total antioxidant capasity(TAOC) in smoking and non-smoking patients with severe chronic periodontitis.

Systemically healthy 15 smoker,15 non-smoker with chronic periodontitis were attended for the study. Periodontal status were determined by recording periodontal clinical measurements. GCF samples were collected at the baseline, at the end of initial periodontal treatment and 4 weeks after periodontal flap surgery. The data were tested statistically by the Student t and paired sample t tests.

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Key information

Conditions

Chronic Periodontitis Behavior Chronic Disease Cigarette Smoking Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Smoking Smoking, Cigarette Stomatognathic Diseases Tobacco Smoking Tobacco Use

Age range

35 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Müge Lütfioğlu

Samsun, Atakum, 55039, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

individuals aged ˃35 years and having ≥16 teeth diagnosed as chronic periodontitis
not received any periodontal therapy within the previous 6 months;
not received antibiotic/anti-inflammatory drug treatment within the previous 6 months.

Exclusion criteria

receiving medical treatment for cancer, rheumatoid arthritis, diabetes mellitus, cardiovascular disease, or any other systemic disease;
being pregnant or being in the period of menopause or lactation;
receiving any drug therapy that might affect the clinical characteristics of periodontitis;
usage of systemic antimicrobials during the 6 weeks prior to data collection

Treatment and study plan

Primary outcomes

GCF IL-17A VOLUME

Time frame: GCF sampling was performed prior to periodontal treatment , 4 weeks after completion of initial periodontal treatment, and 4 weeks after periodontal flap surgery .

IL-17A is a cytokine present in gingival crevicular fluid. Its volume calculated as microliter and changes due to inflammation caused by periodontal disease.
GCF IL-17E VOLUME

Time frame: GCF sampling was performed prior to periodontal treatment , 4 weeks after completion of initial periodontal treatment, and 4 weeks after periodontal flap surgery .

IL-17E is a cytokine present in gingival crevicular fluid. Its volume calculated as microliter and changes due to inflammation caused by periodontal disease.
GCF TOTAL OXIDATIVE STRESS (TOS) LEVEL

Time frame: GCF sampling was performed prior to periodontal treatment , 4 weeks after completion of initial periodontal treatment, and 4 weeks after periodontal flap surgery .

TOS is the measurement of oxidative stress amount and given as mmol/L unit. Its amount changes due to inflammation caused by periodontal disease.
GCF TOTAL ANTIOXIDANT CAPASITY (TAOC)

Time frame: GCF sampling was performed prior to periodontal treatment , 4 weeks after completion of initial periodontal treatment, and 4 weeks after periodontal flap surgery .

TAOC is the antioxidant amount measured and given as μmol H2O2 Eq/L unit. Its amount changes due to inflammation caused by periodontal disease.

Sponsors and collaborators

Lead sponsor

Ondokuz Mayıs University

Other

Registry information

Official study title

Smoking Effects on GCF GCF IL-17A AND IL-17 Levels and Oxidative Status of Patients Receiving Periodontal Treatment

Acronym: GCF

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2019
First posted: Oct 3, 2019
Registry last updated: Oct 4, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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