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Active, Not Recruiting

NCT Number: NCT06074198

Sickle Cell Children's Exercise Study (SuCCESs)

The Sickle Cell Children's Exercise Study (SuCCESs) will explore the feasibility and effects of a moderate intensity strengthening, balance, speed, and agility intervention program in children with sickle cell disease.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Sickle Cell Disease Anemia Anemia, Hemolytic Anemia, Hemolytic, Congenital Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Hemoglobinopathies

Age range

6 year–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Maryland School of Medicine Dept. of Physical Therapy & Rehabilitation Science, Baltimore, Maryland, United States

Loading trial locations.

About this study

Participants will perform the baseline assessment and after six weeks of performing the SuCCESs program the participants will perform a post-intervention assessment. Participants will be asked to attend a total of six physical therapy in-person sessions (1x/week) at the University of Maryland Department of Physical Therapy and Rehabilitation Science and to perform 12 home program sessions.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children 6-17 years of age diagnosed with sickle cell disease

Exclusion criteria

  • Diagnosis of neurological disorder, not related to sickle cell disease
  • Lower extremity injury such as a fracture with a cast

Treatment and study plan

SuCCESs

Behavioral

strengthening and endurance exercises

Primary outcomes

  1. knee extension strength

    Time frame: week 1 and week 7

    dynamometry to measure knee extension strength

  2. Rate of Muscle Activation

    Time frame: week 1 and week 7

    Electromyography used to measure rate of muscle activation

  3. exercise tolerance

    Time frame: week 1 and week 7

    6-Minute Walk Test used to measure exercise tolerance

  4. locomotor efficiency

    Time frame: week 1 and week 7

    oxygen uptake used to measure locomotor efficiency

  5. number of sessions attended

    Time frame: throughout the entire study week 1, weeks 2-6, six weeks of intervention, and week 7

    attendance

Sponsors and collaborators

Lead sponsor

University of Maryland, Baltimore

Other

Registry information

Official study title

Sickle Cell Children's Exercise Study Determining the Effects of a Targeted Exercise Training Program on Neuromuscular Performance, Locomotor Efficiency, and Exercise Tolerance in Children With Sickle Cell Disease.

Acronym: SuCCESs

Important dates

Study start
2023
Primary completion
2025
Study completion
2026
First posted
Oct 10, 2023
Registry last updated
Apr 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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