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OpenTrials
Completed

NCT Number: NCT03003988

Physiological Effects of Creatine Supplementation in Active Males

This study was designed to examine how different forms of creatine impact active males.

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Key information

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

About this study

This study examined the effects of different formulations of creatine nitrate on muscle creatine content, body composition, anaerobic exercise capacity, bench press performance and clinical chemistry panels in recreationally active males.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • participants are apparently healthy and recreationally active males between the ages of 18 and 40;
  • participants will need to have at least six months immediate prior history of resistance training on the bench press and leg press or squat;

Exclusion criteria

  • participants have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmias and/or cardiovascular disease;
  • participants are currently using prescription medications;
  • participants have a history of smoking;
  • participants drink excessively (i.e., 12 drinks per week or more);
  • participants have a recent history of creatine supplementation within six weeks of the start of supplementation;

Treatment and study plan

Creatine Monohydrate

Dietary Supplement

Creatine monohydrate (6.0 g) + dextrose (0.5 g)

Creatine nitrate

Dietary Supplement

Creatine nitrate (5.0 g creatine monohydrate + 1.5 g. creatine nitrate that provides 1.0 g. of creatine and 0.5 g. nitrate in 2:1 ratio)

Placebo

Dietary Supplement

Placebo (6.5 g dextrose)

Primary outcomes

  1. Effects of 28 Days of Different Forms of Creatine Supplementation on Body Water

    Time frame: 28 Days

    Assessing Body Water through Bioelectrical Impedance Analysis (BIA)

  2. Effects of 28 Days of Different Forms of Creatine Supplementation on Body Composition

    Time frame: 28 Days

    Assessing Body Compositing through Dual-Energy X-Ray Absorptiometry (DXA)

  3. Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular creatine

    Time frame: 28 Days

    Assessing intramuscular creatine using standard spectrophotometric methods using a microplate spectrophotometer

  4. Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular phosphocreatine

    Time frame: 28 Days

    Assessing intramuscular phosphocreatine using standard spectrophotometric methods using a microplate spectrophotometer

  5. Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular ATP

    Time frame: 28 Days

    Assessing intramuscular Adenosine Triphosphate (ATP) using standard spectrophotometric methods using a microplate spectrophotometer

  6. Effects of 28 Days of Different Forms of Creatine Supplementation on muscular strength

    Time frame: 28 Days

    Assessing muscular strength through 1 Repetition Maximum (RM) testing

  7. Effects of 28 Days of Different Forms of Creatine Supplementation on muscular endurance

    Time frame: 28 Days

    Assessing muscular endurance through repetition to failure testing

  8. Effects of 28 Days of Different Forms of Creatine Supplementation on anaerobic capacity

    Time frame: 28 Days

    Assessing anaerobic capacity through 6 x 6 second sprints followed by a 30 second sprint on a Wingate bicycle ergometer

Secondary outcomes

  1. Effects of 28 Days of Different Forms of Creatine Supplementation on training volume (weight lifted x number of repetitions x number of sets)

    Time frame: 28 Days

    Assessing training volume using a calculator

  2. Effects of 28 Days of Different Forms of Creatine Supplementation on self-reported side effects

    Time frame: 28 Days

    Assessing self-reported side effects using a side effects questionnaire

  3. Effects of 28 Days of Different Forms of Creatine Supplementation on blood

    Time frame: 28 Days

    Measure standard clinical chemistry panels in the blood to evaluate safety

Sponsors and collaborators

Lead sponsor

Texas A&M University

Other

Collaborators

  • Nutrabolt

Registry information

Official study title

Effects of 28 Days of Different Forms of Creatine Supplementation on Muscle Creatine, Body Composition and Exercise Performance in Recreationally Active Males

Acronym: NB4

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Dec 28, 2016
Registry last updated
Jan 4, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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