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Completed

NCT Number: NCT05116150

Effects of Combined Grape Seed Extract and L-citrulline Supplementation on Hemodynamic Responses in Young Males

This study was to examine the additive benefits with combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study.

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Key information

Conditions

Dietary Supplementation

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

California Baptist University

Riverside, California, 92504, United States

About this study

The investigators aimed the additive effects of combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study. Effects of 7 days of combined GSE with L-citrulline supplementation on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), cardiac output (CO), total vascular conductance (TVC), and oxygen consumption (O2) were examined at rest and during cycling exercise.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy males

Exclusion criteria

  • cardiovascular and/or pulmonary disease, musculoskeletal disorders, or medications that prevent the safe completion of the exercise protocol

Treatment and study plan

Grape seed extract

Dietary Supplement

Effects of 7 days of combined GSE with L-citrulline supplementation on hemodynamic responses at rest and during cycling exercise.

Placebo

Dietary Supplement

Effects of 7 days of placebo supplementation on hemodynamic responses at rest and during cycling exercise.

Primary outcomes

  1. Systolic blood pressure (mmHg)

    Time frame: 7 days

    by sphygmomanometer

  2. Diastolic blood pressure (mmHg)

    Time frame: 7 days

    by sphygmomanometer

  3. Mean arterial pressure (mmHg)

    Time frame: 7 days

    calculated (MAP = (SBP-DBP)/3 + DBP

  4. Heart rate (bpm)

    Time frame: 7 days

    measured using Physio Flow (non-invasive device)

  5. Stroke volume (ml)

    Time frame: 7 days

    measured using Physio Flow (non-invasive device)

  6. Cardiac output (l/min)

    Time frame: 7 days

    calculated: HR (bpm) x SV (ml)

  7. Total vascular conductance (ml/min/mmHg)

    Time frame: 7 days

    calculated: CO (ml/min) / MAP (mmHg)

Sponsors and collaborators

Lead sponsor

California Baptist University

Other

Registry information

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Nov 10, 2021
Registry last updated
Nov 10, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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