Skip to main content
OpenTrials
Completed

NCT Number: NCT05945771

Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Dietary Supplementation

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

California Baptist University

Riverside, California, 92504, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers (SBP < 120 mmHg, DBP < 80 mmHg)

Exclusion criteria

  • cardiovascular and/or pulmonary disease,
  • musculoskeletal disorders
  • medications that prevent the safe completion of the exercise protocol

Treatment and study plan

Grape seed extract

Dietary Supplement

Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise.

Primary outcomes

  1. Systolic blood pressure (mmHg) by sphygmomanometer

    Time frame: 24 hours

    Measured from the brachial artery

  2. Diastolic blood pressure (mmHg) by sphygmomanometer

    Time frame: 24 hours

    Measured from the brachial artery

  3. Mean arterial pressure (mmHg)

    Time frame: 24 hours

    calculated (MAP = (SBP-DBP)/3 + DBP

  4. Heart rate (bpm)

    Time frame: 24 hours

    measured using Physio Flow (non-invasive device)

  5. Stroke volume (ml)

    Time frame: 24 hours

    measured using Physio Flow (non-invasive device)

  6. Cardiac output (l/min)

    Time frame: 24 hours

    calculated: HR (bpm) x SV (ml)

  7. Total peripheral resistance (mmHg/l/min)

    Time frame: 24 hours

    calculated: MAP (mmHg) / CO (l/min)

Sponsors and collaborators

Lead sponsor

California Baptist University

Other

Registry information

Official study title

Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Jul 14, 2023
Registry last updated
Jul 14, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.