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NCT Number: NCT07633782

High-Intensity Focused Electromagnetic Therapy on Patients With Patellofemoral Pain Syndrome

Evaluate the effect of High-Intensity Focused Electromagnetic Therapy on pain, quadriceps strength, and quality of life in patients with patellofemoral pain syndrome

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Key information

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Patients diagnosed with patellofemoral pain syndrome will be recruited from outpatient physical therapy clinics. Following a comprehensive clinical screening, eligible participants will be randomly assigned into two parallel groups:

The Study Group: Will receive true High-Intensity Focused Electromagnetic Therapy sessions plus a traditional physiotherapy program for 8 weeks.

The Control Group: Will receive sham High-Intensity Focused Electromagnetic Therapy sessions plus the same traditional physiotherapy program for 8 weeks.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of patellofemoral pain syndrome (anterior or peripatellar knee pain aggravated by at least two activities such as stair climbing, prolonged sitting, squatting, or running).
  • Symptoms persisting for at least 3 months.

Exclusion criteria

  • History of previous knee surgery or trauma (e.g., ligamentous laxity, meniscal tear, or patellar fracture).
  • Concomitant knee pathology (e.g., tibiofemoral osteoarthritis, patellar tendinopathy, or plica syndrome).
  • Presence of metallic implants, pacemakers, or electrical medical devices in the body .
  • Recent corticosteroid or hyaluronic acid injection into the affected knee within the last 3 months.
  • Pregnancy.

Treatment and study plan

True High-Intensity Focused Electromagnetic Therapy

Device

20-30 minute sessions, 2-3 times per week for 8 weeks at a clinically effective, tolerable intensity level designed to elicit supramaximal contractions for the quadriceps muscle.

Sham high-intensity focused electromagnetic therapy

Device

The device protocol, application time, and acoustic feedback will the same as the experimental arm, but with the device in the off state and no muscular contractions in the quadriceps muscle .

traditional physiotherapy

Other

Standard rehabilitation program including patellar mobilization with quadriceps and hip abductor strengthening.

Primary outcomes

  1. Pain level

    Time frame: Baseline and after 8 weeks

    Visual Analog Scale will be used to assess pain

Secondary outcomes

  1. Quadriceps muscle strength

    Time frame: Baseline and after 8 weeks

    Isokinetic dynamometry will be used for assessing quadriceps muscle strength

  2. Health-related quality of life

    Time frame: Baseline and after 8 weeks

    Short Form-12 Health Survey (SF-12) will be used to assess QoL

Study contacts

Contact information is provided by the study sponsor or research team.

Mohammed Youssef Elhamrawy, Ph.D

CONTACT

[email protected]

+201282805567

Saher Lotfy Elgayar, Ph.D

CONTACT

[email protected]

+201020429911

Sponsors and collaborators

Lead sponsor

Middle East University

Other

Registry information

Official study title

Effect of High-Intensity Focused Electromagnetic Therapy on Pain and Quality of Life in Patients With Patellofemoral Pain Syndrome: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 8, 2026
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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