Skip to main content
OpenTrials
Completed

NCT Number: NCT01079624

GIP and GLP-1 on Gastric Emptying, Appetite and Insulin-glucose

Academic phase 1 study which investigates the effects of the two incretin hormones glucose-insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) on gastric emptying, appetite, insulin release and glucose disposal in the body. The hypothesis is that incretin hormones not only stimulate insulin release but also inhibits gastric emptying. This effect can be utilized for further drug development.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Physiology Endocrinology Gastroenterology

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Karolinska University Hospital

Stockholm, Stockholm County, 17176, Sweden

About this study

Effects of GIP and GLP-1 on gastric emptying, appetite control and insulin release in relation to glucose levels in the bloodstream. Infusions of GIP and GLP-1 are given under simultaneous gastric emptying study and appetite questionnaires and blood sampling for analysis of insulin, glucose, and other gut hormones such as glucagon, ghrelin, and PYY, as well as those administered, GIP and GLP-1.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women
  • 18-50 years old;
  • otherwise healthy and HIV and HCB, HCV negative

Exclusion criteria

  • Age >50,
  • all types of diseases and drug users.

Treatment and study plan

Glucose-insulinotropic peptide, Glucagon-like peptide-1

Other

GIP 2 and 5 pmol/kg min GLP-1 0.7 pmol/kg min

Other names: GIP, GLP-1, Saline

Primary outcomes

  1. Gastric emptying rate

    Time frame: 2005-2006

Secondary outcomes

  1. Plasma glucose, insulin release, appetite

    Time frame: 2005-2006

Sponsors and collaborators

Lead sponsor

Uppsala University

Other

Collaborators

  • Karolinska Institutet
  • University of Copenhagen

Registry information

Official study title

Effects of GIP and GLP-1 on Gastric Emptying, Appetite and Insulin-glucose Homeostasis

Acronym: GIP-GLP-gas

Important dates

Study start
2006
Primary completion
2008
Study completion
2009
First posted
Mar 3, 2010
Registry last updated
Mar 3, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.