Evaluation of the Salivary-free Amino Acids Levels (Glycine , Proline , Lysine , and Alanine ) With Caries Activity

This study will be aimed to investigated the correlation between levels of salivary amino acids (glycine , proline , lysine , alanine ) in the saliva of healthy children with and without active carious lesions and to estimate the predictive capacity of caries susceptibility

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Key information

Conditions

Dental Caries Stomatognathic Diseases Tooth Demineralization Tooth Diseases

Age range

8 year–10 year

Sex eligibility

All sexes

Study type

Observational

About this study

80 healthy children (8-10 years old) will be recruited from primary schools of Baghdad city/ Iraq, will be classified according to their level of caries activity (high caries activity, n = 40; negative caries activity, n = 40). Total stimulated and unstimulated saliva will be collected to estimate the caries activity by using the Snyder test, and Amino acid analysis of the saliva will be performed by reversed phase - high performance liquid chromatography (RP-HPLC), respectively.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Children aged (8,9,10) years with different caries
Absence of signs of gingivitis or periodontal disease.

Exclusion criteria

Children out the range of age
Children with any systemic discases.
Children with appliances in the mouth.
Children with appliances in the mouth.
Children with antibiotic treatment or any other drug over the last two weeks. B

Treatment and study plan

To compare the effect of salivary glycine , proline , lysine and alanine concentration between participants with high caries activity and participants with negative caries activity

Diagnostic Test

The investigators will measure Salivary-free amino acids by using reverse phase high performance liquid chromatography

Primary outcomes

Salivary-free amino acid analysis

Time frame: Baseline :unstimulated saliva collection for salivary glycine , proline , lysine and alanine measurement

Unstimulated saliva collection for salivary free amino acids analysis

Study contacts

Contact information is provided by the study sponsor or research team.

Abeer Ibrahim Mohammed, B.D.S

CONTACT

[email protected]

+9647709497799

Sponsors and collaborators

Lead sponsor

Al-Mustansiriyah University

Other

Registry information

Official study title

Evaluation of the Salivary-free Amino Acids Levels With Caries Activity

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: May 1, 2025
Registry last updated: May 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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