Salivary Cytokines, MMP-8 and Dental Caries in Osteoporosis Patients

This study examines saliva samples from patients with osteoporosis. The levels of cytokines and Matrix Metalloproteinase-8 (MMP-8) enzyme in saliva will be measured. Additionally, the dental caries status of participants will be evaluated. The aim of this study is to understand the relationship between osteoporosis and oral health. Only saliva samples will be collected from participants; no treatment or medication will be administered.

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Key information

Conditions

Osteoporosis Biomarkers Bone Diseases Bone Diseases, Metabolic Dental Caries Matrix Metalloproteinase 8 Metabolic Diseases Musculoskeletal Diseases Nutritional and Metabolic Diseases Stomatognathic Diseases Tooth Demineralization Tooth Diseases

Age range

45 year–75 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Willing to give voluntary consent For Group 1, having been diagnosed with osteoporosis For Group 2, being systemically healthy and not having a diagnosis of osteoporosis/osteopenia

Exclusion criteria

Having a chronic inflammatory or autoimmune disease Using glucocorticoids, anti-anxiety medications, antidepressants, or antiepileptic drugs Having been diagnosed with any malignancy Having any endocrine disease Having undergone periodontal treatment within the last 6 months

Treatment and study plan

Primary outcomes

Salivary Cytokine Levels

Time frame: day 1

Measurement of cytokine levels in saliva samples collected from osteoporosis patients

Study contacts

Contact information is provided by the study sponsor or research team.

Kübra Karaçam, Asist.Prof.

CONTACT

[email protected]

+905059396258

Sponsors and collaborators

Lead sponsor

Afyonkarahisar Health Sciences University

Other

Registry information

Official study title

Osteoporoz Hastalarında Tükürük Sitokin, Matrix Metalloproteinase 8 ve Diş Çürüğünün Değerlendirilmesi

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2027
First posted: Jul 16, 2026
Registry last updated: Jul 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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