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NCT Number: NCT07124533

Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences

Objectives: To evaluate the effectiveness of toothpaste tablets when compared to conventional dentifrices in removing plaque.

Methods: 50 participants are randomized into two groups: Denttabs toothpaste tablets (T) and Colgate's Cavity Protection toothpaste (P). Both groups utilize their assigned dentifrice for 6 weeks. A pre and post-assessment measures the Gingival Index (GI) and Plaque Index (PI) and Decayed, Missing and Filled Teeth (DMFT). A questionnaire on the use of the product is distributed at the end of the study.

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Key information

Conditions

Gingival Inflammation Behavior Consumer Behavior Dental Caries Gingival Diseases Gingivitis Infections Mouth Diseases Periodontal Diseases Stomatognathic Diseases Tooth Demineralization Tooth Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Loma Linda University, Loma Linda, California, United States

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects are 18 years or older;
  • Subjects who will comply with study protocol;
  • Subjects who can read and understand the consent form;
  • Subjects available during the study period;
  • Subjects have more than 20 teeth.

Exclusion criteria

  • Subjects under the age of 18.

Treatment and study plan

Toothpaste Tablet

Drug

Denttabs toothpaste tablets

Other names: Denttabs Toothpaste Tablets

Conventional Toothpaste

Drug

Colgate Cavity Protection toothpaste

Other names: Colgate Cavity Protection

Primary outcomes

  1. Plaque Index Score at Baseline

    Time frame: Change between baseline at visit 1 and visit 2, six weeks post baseline

    The quantity of plaque build-up is measured visually using the Quigley-Hein Plaque Index. The Plaque index can range from 0 to 5, with higher numbers indicating more plaque build-up.

  2. Gingival Index Score at Baseline

    Time frame: Change between baseline at visit 1 and visit 2, six weeks post baseline

    The severity of gingival inflammation is measured visually using the Loe-Silness Gingival Index. Gingival index can range from 0 to 3, with higher numbers indicating more gingival inflammation.

Secondary outcomes

  1. DMFT Score at Baseline

    Time frame: Change between baseline at visit 1 and visit 2, six weeks post baseline

    Caries experiences is measured visually using the DMFT index. DMFT score can range from 0 to 28, with higher numbers indicating higher caries experiences.

  2. Subject Perception of Product Use

    Time frame: Visit 2 six weeks post study enrollment

    The perception on the product usage is measured using a survey containing questions on feel, texture, flavor, ease of use, eco-friendliness, cost and overall satisfaction. Response is on a 4 point Likert scale ranging from strongly agree (1) to strongly disagree (4).

Study contacts

Contact information is provided by the study sponsor or research team.

So Ran Kwon, DDS, MS, PhD

CONTACT

[email protected]

909 558 5118 ext. 55118

Sponsors and collaborators

Lead sponsor

Loma Linda University

Other

Registry information

Official study title

Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences: A 6-week Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 15, 2025
Registry last updated
Jul 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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