CHOICES3: Sickle Cell Disease Parenting CHOICES

In a 2-year, randomized, longitudinal, repeated measures, controlled trial in 430 at-risk young adults with SCD (50%) or SCT (50%) to compare the effects of e-Book (electronic-Book) and CHOICES interventions on knowledge and behaviors across time (baseline, immediate posttest, 6, 12, 18, 24 months). The study will provide boosters tailored to knowledge deficits at 6 and 12 months and add monthly reinforcement nudges toward concordant behavior during the first 12 months.

Inclusion criteria

• Diagnosis of SCD (HbSS, HbSC (Hemoglobin Sickle C Disease), HbS-beta-0 thalassemia, and HbS-beta+ thalassemia) or report of SCT (SCD is Hgb electrophoresis confirmed; SCT evaluated by SickleScan);
• Able and intends to conceive a child in the next 2 years (first child or another child);
• Speaks and reads English;
• 18 to 45 years;
• At-risk for having a child with SCD (i.e., sexual/ reproductive partner has SCD, SCT, or unknown sickle cell status); and
• Wants to avoid the risk of a child with SCD.
• The age range is based on typical reproductive age for SCD where median survival is 42 years for men and 48 years for women.

Exclusion criteria

• Legally blind;
• Physically unable to complete the study questionnaires or the intervention;
• Report health history of hysterectomy, tubal ligation, medically or surgically induced menopause, or vasectomy that would
• Prevent ability to bear children;
• Report a desire to remain childless or have no further children;
• Report knowing or being a relative or friend of a participant previously enrolled in the study, or
• Previous participation in a CHOICES study.