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Clinical trial condition

Heredodegenerative Disorders, Nervous System

Explore clinical trials studying Heredodegenerative Disorders, Nervous System. Study availability and eligibility vary by location and protocol.

1,879 public trials 409 recruiting studies
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Heredodegenerative Disorders, Nervous System trial results

Completed

Phase IIIb, Open-label, Multi-center Study to Evaluate Safety, Tolerability and Efficacy of OAV101 Administered Intrathecally to Participants With SMA Who Discontinued Treatment With Nusinersen or Risdiplam

NCT05386680

Conditions
Atrophy, Bulbo-Spinal Atrophy, X-Linked, Central Nervous System Diseases, +19 more
Locations
  • Boston Childrens Hospital Boston, Massachusetts, United States
  • Child Hosp Of The Kings Daughters Norfolk, Virginia, United States
  • University of Wisconsin Madison Medical School Madison, Wisconsin, United States
  • Novartis Investigative Site Parkville, Victoria, Australia
View all 13 locations
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Completed

Efficacy and Safety of Intrathecal OAV101 (AVXS-101) in Pediatric Patients With Type 2 Spinal Muscular Atrophy (SMA)

NCT05089656

Conditions
Atrophy, Central Nervous System Diseases, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, +18 more
Locations
  • Connecticut Children's Medical Center Farmington, Connecticut, United States
  • Ann & Robert H. Lurie Children's Hospital of Chicago Chicago, Illinois, United States
  • Clinic for Special Children Strasburg, Pennsylvania, United States
  • St Jude Children's Research Hospital Memphis, Tennessee, United States
View all 42 locations
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Completed

Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant or Letrozole, Based on Prior Endocrine Therapy, in Patients With PIK3CA Mutant, HR+, HER2- Advanced Breast Cancer Who Have Progressed on or After Prior Treatments

NCT03056755

Conditions
Breast Cancer, Breast Diseases, Breast Neoplasms, +15 more
Locations
  • Banner MD Anderson Cancer Center Gilbert, Arizona, United States
  • Mayo Clinic Arizona Phoenix, Arizona, United States
  • Kaiser Permanente Medical Group Anaheim, California, United States
  • Beverly Hills Cancer Center Beverly Hills, California, United States
View all 94 locations
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Completed

Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies

NCT05054725

Conditions
Bronchial Diseases, Bronchial Neoplasms, Carcinoma, +23 more
Locations
  • Florida Cancer Specialists Fort Myers, Florida, United States
  • BRCR Medical Center Inc. Plantation, Florida, United States
  • Cancer Specialists of North Florida Saint Augustine, Florida, United States
  • GenHarp Clinical Solutions Evergreen Park, Illinois, United States
View all 60 locations
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Completed

Validation of Molecular Diagnostic Assays to Detect Cancer Biomarkers in Blood & Primary Tumor in ER+/HER2- MBC

NCT04480814

Conditions
Breast Cancer, Breast Diseases, Breast Neoplasms, +15 more
Locations
  • University General Hospital of Alexandroupoli Alexandroupoli, Alexandroupolis, Greece
  • Aretaieio University Hospital of Athens Athens, Attica, Greece
  • University General Hospital of Athens Attikon Athens, Attica, Greece
  • Metropolital Hospital Piraeus, Greece
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