Ventilator Weaning Practices in Patients Intubated for Guillain-Barré Syndrome or Myasthenia Gravis

Guillain-Barré syndrome and myasthenia gravis are two neuromuscular diseases that are commonly managed in ICUs that may require different weaning protocols. To date, no study has compared weaning modalities from mechanical ventilation in patients with these two diseases. Our objective was to assess and compare for ventilator weaning modalities between patients mechanically ventilated for Guillain-Barré syndrome or for myasthenia gravis in a large-scale multicenter study.

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Key information

Conditions

Myasthenia Gravis Autoimmune Diseases Autoimmune Diseases of the Nervous System Chronic Disease Demyelinating Diseases Disease Attributes Guillain-Barre Syndrome Immune System Diseases Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms Neurodegenerative Diseases Neuromuscular Diseases Neuromuscular Junction Diseases Paraneoplastic Syndromes Paraneoplastic Syndromes, Nervous System Pathologic Processes Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Polyneuropathies Polyradiculoneuropathy Post-Infectious Disorders

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de POITIERS

Poitiers, 86000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All patients mechanically ventilated for at least 48 hours for Guillain-Barré syndrome or myasthenia gravis -

Exclusion criteria

Patients mechanically ventilated less than 48h or intubated for another reason than the neuromuscular disease.

Treatment and study plan

Primary outcomes

The proportion of patients with prolonged weaning

Time frame: 7 days after the initial separation attempt from the ventilator

Prolonged weaning defined as still being under mechanical ventilation at least 7 days after the initial separation attempt from the ventilator

Sponsors and collaborators

Lead sponsor

Poitiers University Hospital

Other

Registry information

Acronym: GUIMAUVE

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Jun 15, 2025
Registry last updated: Jun 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed