Skip to main content
OpenTrials
Completed

NCT Number: NCT03941184

Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity

This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

SCAD Addison Disease Adrenal Gland Diseases Adrenal Insufficiency Anemia Anemia, Macrocytic Anemia, Megaloblastic Anemia, Pernicious Ankylosing Spondylitis Ankylosis Antiphospholipid Antibody Syndrome Antiphospholipid Syndrome Aortic Arch Syndromes Aortic Diseases Arteritis Arthritis Arthritis, Rheumatoid Autoimmune Diseases Autoimmune Diseases of the Nervous System Avitaminosis Axial Spondyloarthritis Bile Duct Diseases Biliary Tract Diseases Bone Diseases Cardiovascular Diseases Celiac Disease Cholestasis Cholestasis, Intrahepatic Chronic Disease Colitis Colitis, Ulcerative Colonic Diseases Connective Tissue Diseases Coronary Artery Dissection, Spontaneous Crohn Disease Deficiency Diseases Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Dermatomyositis Diabetes Mellitus Diabetes Mellitus, Type 1 Digestive System Diseases Disease Attributes Dry Eye Syndromes Endocrine System Diseases Exophthalmos Eye Diseases Fibrosis Gastroenteritis Gastrointestinal Diseases Glucose Metabolism Disorders Goiter Graves Disease Guillain-Barre Syndrome Hashimoto Disease Hashimoto Thyroiditis Hematologic Diseases Hemic and Lymphatic Diseases Hepatitis Hepatitis, Autoimmune Hepatitis, Chronic Hyperthyroidism Hypopigmentation Immune System Diseases Inflammatory Bowel Diseases Intestinal Diseases Joint Diseases Lacrimal Apparatus Diseases Liver Cirrhosis Liver Cirrhosis, Biliary Liver Diseases Lupus Erythematosus, Systemic Malabsorption Syndromes Malnutrition Metabolic Diseases Mouth Diseases Multiple Sclerosis Muscular Diseases Musculoskeletal Diseases Myasthenia Gravis Myositis Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms Neurodegenerative Diseases Neuromuscular Diseases Neuromuscular Junction Diseases Nutrition Disorders Nutritional and Metabolic Diseases Orbital Diseases Paraneoplastic Syndromes Paraneoplastic Syndromes, Nervous System Pathologic Processes Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Pernicious Anemia Pigmentation Disorders Polymyalgia Rheumatica Polymyositis Polyneuropathies Polyradiculoneuropathy Post-Infectious Disorders Primary Biliary Cirrhosis Psoriasis Raynaud Rheumatic Diseases Rheumatoid Arthritis Salivary Gland Diseases Scleroderma, Systemic Sjogren's Syndrome Sjögren Syndrome Skin Diseases Skin Diseases, Papulosquamous Skin Diseases, Vascular Skin and Connective Tissue Diseases Spinal Diseases Spondylarthritis Spondylarthropathies Spondylitis Spondylitis, Ankylosing Stomatognathic Diseases Systemic Lupus Erythematosus Systemic Sclerosis Takayasu Arteritis Thyroid Diseases Thyroiditis Thyroiditis, Autoimmune Type 1 Diabetes Mellitus Ulcerative Colitis Uveal Diseases Uveitis Vascular Diseases Vasculitis Vitamin B 12 Deficiency Vitamin B Deficiency Vitiligo Xerostomia

Age range

18 year–110 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults age 18 to 110
  • Residence in Olmsted County. Note: if sufficient numbers cannot be reached using only Olmsted County, will expand to the 27-county region.

Exclusion criteria

  • None

Treatment and study plan

Primary outcomes

  1. Odds of autoimmune disease in SCAD cases compared to controls

    Time frame: Through study completion, or approximately 50 years (average age of study participants)

  2. Incidence Rate of SCAD

    Time frame: Through study completion, or approximately 50 years (average age of study participants)

Secondary outcomes

  1. SCAD recurrence

    Time frame: Through study completion, or approximately 50 years (average age of study participants)

Other outcomes

  1. Odds of laboratory markers for autoimmune disease in SCAD cases compared to controls

    Time frame: Through study completion, or approximately 50 years (average age of study participants)

  2. Odds of validated rheumatoid arthritis in SCAD cases compared to controls

    Time frame: Through study completion, or approximately 50 years (average age of study participants)

    using the Rochester Epidemiology Project Rheumatoid Arthritis cohort

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

Determining the Association Between Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity

Important dates

Study start
1995
Primary completion
2020
Study completion
2020
First posted
May 7, 2019
Registry last updated
Nov 23, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.