Variations of Portal Flow During the Respiratory Cycle in Healthy Volunteers

The analysis of portal vein blood flow is important when assessing the severity and progression of liver disease. It is important to understand normal liver regulation in order to appreciate the evaluation of the effect of treatment during the disease progression. The influence of respiration on hepatic hemodynamics is still poorly understood, although some studies have shown a significant impact. The purpose of this project is to quantify the blood flow variations in the portal vein at different positions during the respiratory cycle by using a fast MRI sequence and an Echo Planar (EPI) acquisition.

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Key information

Conditions

Respiratory Amplitude Echo Planar Imaging MRI Portal Blood Flow

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Amiens

Amiens, 80480, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 18 ans
Healthy subject without history of hepatic disease

Exclusion criteria

history of hepatic pathology
pregnant woman
claustrophobia
major obesity
any contraindication to MRI exam

Treatment and study plan

peripheral ECG

Other

Subjects will be placed in supine position. The systematic use of a headset will reduce the noise inherent to the machine. A cardiac synchronization system using peripheral ECG allows the synchronization with the subject's heart rate.

Standard MRI

Other

Standard MRI examination using a torso coil consists of morphological and phase-contrast flow sequences(standard and EPI acquisitions).

Primary outcomes

flow rates variation between the fast sequence averaged values and the standard sequence

Time frame: 30 minutes

flow rates variation between the fast sequence averaged values and the standard sequence during free breathing.

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: RESPIFLUX

Important dates

Study start: 2021
Primary completion: 2023
Study completion: 2024
First posted: Mar 4, 2021
Registry last updated: May 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed