Evaluation of Anterior Cruciate Ligament Tears Using Diffusion Tractography

Knees injuries commonly affect the ACL. French current methodology is based on MRI focused on the knee with morphological sequences (T1, DP fat sat) allowing the study of ACL as follows: No lesion / Partial tear / Complete tear.

The treatment (kinesitherapy, surgery, no intervention) is defined taking into account several factors such as age, knee laxity, physical activity and outcome of the radiology analysis (partial or complete tear). However, if the classification is straightforward in case of complete tear, it is not possible to establish a quantitative impact on the ACL in case of partial tear. As a consequence, the investigators will analyze the anisotropy coefficient with diffusion tractography. Any patient who undergo a posttraumatic knee MRI at the CHU Amiens Picardie will have an appointment at the 3T "Signa" MRI that has the knee-centric diffusion tractography sequence.

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Key information

Conditions

ACL Injury Anterior Cruciate Ligament Injuries Knee Injuries Leg Injuries MRI Tractography Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Amiens Picardie

Amiens, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 18 years old,
Patient referred for non-enhanced knee MRI for traumatism.
Affiliation to a social security program,

Exclusion criteria

Person under guardianship or curators,
Any contraindications to MRI

Treatment and study plan

tractography MRI sequence protocol

Other

tractography MRI sequence protocol does not require injection of contrast agent.

Primary outcomes

Anisotropy score after tractography MRI sequence

Time frame: one day

Anisotropy coefficient value is between 0 (isotropic medium) to 1 (fibrillar medium) .

Anisotropy coefficient =0 is for total ACL rupture Anisotropy coefficient between 0 end 0.8 is for partial ACL rupture
Correlation between anisotropy coefficient and ACL lesion state

Time frame: one year

Anisotropy coefficient value is between 0 (isotropic medium) to 1 (fibrillar medium) .

Anisotropy coefficient =0 is for total ACL rupture ACL lesion state are No lesion, Partial tear or Complete tear

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: TRACTOLCA

Important dates

Study start: 2023
Primary completion: 2026
Study completion: 2026
First posted: Apr 10, 2023
Registry last updated: Jun 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed