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OpenTrials
Completed

NCT Number: NCT07681193

Effects of Whole Body Vibration on Quadriceps Function, Landing Biomechanics, and Performance in Individuals With ACL Reconstruction

Individuals who undergo anterior cruciate ligament reconstruction (ACLR) are at heightened risk of secondary anterior cruciate ligament (ACL) injury (e.g. additional injury to the ACL in either knee). One of the primary physiological consequences of ACLR is the presence of quadriceps dysfunction (i.e. reduced activation and strength) which has been linked to altered gait and landing biomechanics. Aberrant landing biomechanics have been associated with an increased risk of both primary and secondary ACL injury, thus additional research is needed to evaluate the efficacy of treatments aimed to reduce quadriceps dysfunction and restore adequate landing biomechanics in attempts to reduce secondary ACL injury. Whole-body Vibration (WBV) has demonstrated success in improving quadriceps function and gait biomechanics in individuals with ACLR, however its effectiveness on landing biomechanics is unknown. To evaluate the acute effects of WBV on landing biomechanics in those with ACLR, a non-randomized crossover-controlled trial was conducted to determine if a single bout of WBV improved landing biomechanics greater than a control condition. Participants completed two separate testing sessions (separated by at least one week) in which measures of quadriceps function and landing biomechanics were assessed before and after either a control (no WBV) or WBV intervention. Separate linear mixed-effects models of post-test values for each dependent outcome were conducted with condition (control vs WBV) and limb (ACLR vs Uninvolved) as an interaction term, and each condition pre-test values and time post-ACLR as fixed effect covariates and a random effect of subject. The investigators expect to observe a significant improvement in landing biomechanics following WBV compared to the control condition.

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Univesrity of North Carolina at Chapel HIll MOTION Science Institute

Chapel Hill, North Carolina, 27599, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Between the ages of 18-35
  • History of primary, unilateral ACLR
  • Medically cleared for unrestricted physical activity

Exclusion criteria

  • More than 5 years removed from ACLR
  • Currently pregnant
  • History of other lower extremity surgery
  • History of lower extremity injury in previous 6 months
  • History of neurological disorder
  • Maximal isometric quadriceps torque > 3.0 Nm/kg in the ACLR limb

Treatment and study plan

Whole body vibration (WBV)

Other

Participants will stand on a WBV platform in a mini-squat position while vibration is applied during six 60-second bouts with 2 minutes of rest between each bout. WBV will be delivered at an acceleration of 2g and a frequency of 30 Hz.

Sham Whole body vibration

Other

Participants will stand on a WBV platform in a mini-squat position during six 60-second bouts with 2 minutes of rest between each bout. No vibration will be applied.

Primary outcomes

  1. Internal Knee Adduction Moment (KAM)

    Time frame: Separate values prior to and immediately following the intervention (within 5 minutes).

    Peak value during landing in both single-leg and double-leg tasks averaged over 3 trials and normalized to the product of body weight and height

  2. Internal Knee Extension Moment (KEM)

    Time frame: Separate values prior to and immediately following the intervention (within 5 minutes).

    Peak value during landing in both single-leg and double-leg tasks averaged over 3 trials and normalized to a product of body weight*height

  3. Knee Flexion Angle (KFA)

    Time frame: Separate values prior to and immediately following the intervention (within 5 minutes).

    Peak value during landing in both single-leg and double-leg tasks averaged over 3 trials

Secondary outcomes

  1. Dynamic Postural Control

    Time frame: Separate values prior to and immediately following the intervention (within 5 minutes).

    Time-to-stabilization during single-leg landing

  2. Vertical Ground Reaction Force

    Time frame: Separate values prior to and immediately following the intervention (within 5 minutes).

    Peak value during landing in both single-leg and double-leg tasks

  3. Frontal Plane Kinematics

    Time frame: Separate values prior to and immediately following the intervention (within 5 minutes).

    Peak value during landing in both single-leg and double-leg tasks

Sponsors and collaborators

Lead sponsor

University of North Carolina, Chapel Hill

Other

Registry information

Official study title

Use of Whole-body Vibration to Acutely Improve Landing Biomechanics In Individuals With Anterior Cruciate Ligament Reconstruction (ACLR)

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Jul 2, 2026
Registry last updated
Jul 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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