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OpenTrials
Completed

NCT Number: NCT00746889

Using Ultrasound to Predict Response to Intraarticular Corticosteroids in Knee Osteoarthritis

A study using characteristics on ultrasound to predict response to intraarticular steroid injections in patients with knee osteoarthritis. The hypothesis is that patients with inflammation on ultrasound will have a better response to corticosteroid injections compared to patients without inflammation.

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Key information

Conditions

Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

San Diego VA Hospital, La Jolla, California, United States

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • knee pain
  • diagnosis of osteoarthritis in affected knee

Exclusion criteria

  • intraarticular corticosteroids in affected knee within past three months
  • primary inflammatory connective tissue disease (ie rheumatoid arthritis)
  • currently taking oral corticosteroids

Treatment and study plan

Triamcinolone Acetonide

Drug

single intraarticular injection of 40 mg of triamcinolone acetonide

Saline

Drug

Single intraarticular injection of 1 ml of 0.9% saline

Primary outcomes

  1. Change in Western Ontario and McMasters Universities Arthritis Index (WOMAC) Pain Subscale

    Time frame: baseline to 4 weeks

    WOMAC pain subscale range 0-20 (0=best, 20=worst)

Other outcomes

  1. Change in WOMAC Pain Subscale

    Time frame: baseline to 12 weeks

    WOMAC pain subscale range 0-20 (0=best, 20=worst)

Sponsors and collaborators

Lead sponsor

University of California, San Diego

Other

Registry information

Official study title

Using Ultrasound to Predict Response to Intraarticular Corticosteroids in Knee Osteoarthritis: A Randomized Placebo-Controlled Clinical Trial

Important dates

Study start
2004
Primary completion
2008
Study completion
2008
First posted
Sep 4, 2008
Registry last updated
Aug 25, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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