"Using Epigallocatechin Gallate (EGCG) and Cognitive Training to Modulate Cognitive Performance in Patients With Fragile X Syndrome" (TESFX)

Neurophysiology exploration (electroencephalogram)

Evaluates the intellectual status and significantly correlates with the WISC-III.The intellectual quotient (IQ) will correspond to the K-BIT standardized total score, which can range from 40 (very low) to 160 (very high).

To assess psychomotor speed and accuracy. Participants were instructed to touch a series of crosses that appeared randomly on the screen. Response latency (in milliseconds) (MOT: Mean latency [ms]) will be considered in the present study.

explores general alertness and motor speed. Subjects had to press the button on a press pad every time a square appeared in the middle of the screen. Intervals between the examinee's response and the next stimulus were variable during the task.

Forward recall score provides a good measure of verbal attention and working memory span. Backward recall score is predominantly a measure of verbal working memory span. Subjects were required to listen to a series of numbers with randomized presentation, and then repeat them back. The length of the series increased upon the subject's success.

Forward recall is predominantly a measure of visual attention and memory span. Participants were shown a sequence of squares that turned into a different color, one at each time, in a specific temporal order and spatial location. The examinee had to reproduce the sequence by touching on the screen the squares in the same order as they were presented. The length of the sequence increases in accordance to the subject's correct answers. Participants were shown a sequence of squares that turned into a different color, one at each time, in a specific temporal order and spatial location. The examinee had to reproduce the sequence by touching on the screen the squares in the same order as they were presented. The length of the sequence increases in accordance to the subject's correct answers.

Subjects were asked to generate as many words as possible in 1 minute belonging to the specified category of "animals" (open ranged: 0 to n1). High scores (number of words) (Semantic Word Fluency) indicate greater verbal fluency ability.

This test requires moving three different colored balls across three different sized pegs in order to replicate a goal configuration. Movements follow strict rules. Two training tasks were followed by 10 problems of increasing complexity. The task finalized after the examinee failed to solve two consecutive problems.

This is a set-shifting task that assesses the ability to categorize across two dimensions: color and shape. Instructions for administration and scoring were taken from Strauss & Lewin. Test material consisted of 12 tokens: four circles, four triangles, and four squares, and shapes were colored blue, red, yellow or green. The 12 tokens were displayed unsorted in front of the examinee. In the first trial the examinee is required to sort the tokens in a way that they go together (color or shape).

This is a Stroop-like task assessing response inhibition, based on the original Day-Night task. In this test, a sequence of 16 pictures, 8 cats and 8 dogs arranged in a prefixed order, are presented to the examinee on a single strip of card. The task consists of two trials with two different conditions: a control trial and an experimental-inhibition trial.

In this task the participants are required to learn associations between an abstract visual pattern and its location. Each participant is presented with a number of white boxes, arranged in a circle around an empty central space in the screen. Each box "opens" to reveal what is underneath (empty, or with a unique abstract pattern) in a randomized order until the participant has revealed all the contents. Next, a single pattern is presented in the center of the screen and the subject is instructed to touch the box where that pattern has been shown during the presentation phase of the trial. The task increases in difficulty from 1 to 8 patterns.

Participants are presented with a series of two blocks of 12 abstract visual patterns that appear sequentially in the center of the computer screen. Patterns are designed so that they cannot easily be given verbal labels. Each pattern is shown for 3 seconds. In each of the 12 recognition trials, two patterns are presented: one familiar (from the series that the participants have already seen) and one novel pattern. The participant have to recognize the previously seen pattern. The same procedure is repeated with a second block of 12 new patterns but this time the recognition trial started 20 minutes after the presentation of this second block to provide a measure of delayed recall.

The test consisted of a list of 12 items, which have to be verbally recalled by the examinee during 3 trials of free and cued recall. The test start with a learning phase where the examinee is required to learn the list of 12 items using 12 images. Four pictures are presented at a time, one in each quadrant of a card. First, the examinee have to name each of the four pictures in the card, and secondly assign each picture according to a verbal category-cue given by the examiner.

The test consists of 60 black and white pictures graded in naming difficulty. Each picture is presented individually. The examinee is asked to name each item, and when unable to do so spontaneously, the examiner provides semantic and/or phonemic cues.

Test materials consists of 20 tokens in two shapes (circles and rectangles), two sizes (big and small), and five colors (red, black, yellow, white, and green). The tokens are laid out according to a fixed configuration in front of the examinee. The test requires the examinee to touch the tokens according to the oral commands provided by the examiner. Thirty-six commands are divided into six stages of increasing complexity.

ABAS-II is designed, according to AAMS guidelines, for evaluating adaptive skills in people with mental disabilities of a wide age range and across multiple environments. The ABAS-II tool for adults (ages 16 to 89) includes 5 subscales which assesses the individual's competence (in terms of behavior frequency) in 10 different skill áreas.

This instrument assesses quality of life from the child and adolescent's perspective in terms of their physical, mental, and social well-being, higher scores corresponding to a greater quality of life. The questionnaire measures five dimensions.

This questionnaire evaluates the quality and patterns of sleep in older adults. It assesses sleep performance over the previous month across seven different domains: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleep medication, and daytime dysfunction. Parents will self-report all answers to each of the seven areas.

The ABC-C is a 58-item questionnaire for caregivers designed to assess the presence and severity of psychiatric symptoms and behavioral disturbance commonly exhibited by individuals with IDD. The questionnaire explores problem behaviors across 5 domains.

Concentrations of PI3K/mTOR in human lymphocites.

Concentrations in plasma of oxidized- LDL.

Bioimpedance body analysis composition (TANITA)

Concentrations of Kinase 1(ERK) activity in human lymphocytes.