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OpenTrials
Completed

NCT Number: NCT02721693

Troponin T in Chronic Obstructive Pulmonary Disease (COPD) Patients After Physical Exercise

The primary purpose of the study is to investigate if physical exercise is associated with myocardial damage, expressed by elevated troponin T, in patients with COPD.

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Key information

Conditions

COPD Behavior Cardiomyopathies Cardiovascular Diseases Chronic Disease Disease Attributes Heart Diseases Lung Diseases Lung Diseases, Obstructive Motor Activity Myocardial Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

LHL-klinikkene

Hakadal, Akershus, 1485, Norway

About this study

Patients with COPD will perform a cardiopulmonary exercise test (CPET) on treadmill until exhaustion, 8-12 minutes. Venous blood will be drawn before exercise test and 15 minutes, 3 hours and 24 hours after test for analysis of high sensitive Cardiac troponin T (hs-cTnT). The investigators will also measure arterial bloodgas, oxygen uptake, carbon dioxide consumption, ventilation, blood pressure, ECG, heart rate and ask for dyspnea-score.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • COPD
  • GOLD 2-4
  • BODE-index ≥ 2
  • Referred by physician to a CPET

Exclusion criteria

  • Other serious pulmonary diseases (e.g. cancer, sarcoidosis, restrictive pulmonary diseases)
  • Chronic heart disease with unstable angina or myocardial infarction ≤ 3 months prior to inclusion
  • Percutaneous coronary intervention (PCI)
  • Hypertension that is not controlled

Treatment and study plan

Treadmill exercise test

Device

Patients are subjected to an incremental exercise test to exhaustion on a treadmill

Primary outcomes

  1. Troponin T concentration 3 h

    Time frame: 3 h

Sponsors and collaborators

Lead sponsor

LHL Helse

Other

Registry information

Official study title

COPD, Physical Exercise and Troponin T

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Mar 29, 2016
Registry last updated
Oct 11, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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