Skip to main content
OpenTrials
Completed

NCT Number: NCT05825638

Evolution of Pulsed Oxygen Saturation During Interval Training Compared to Continuous Training in COPD Patients

A problem often observed during exercise training is oxygen desaturation exclusively during exercise in some patients. In the case of exercise-induced desaturation, it may be suggested to train these patients in interval training to limit exercise-induced desaturation. Interval training consists of alternating active phases of short duration (often 30 seconds to 1 minute) followed by a short active or passive recovery phase of equivalent duration to the previous phase. Investigators therefore hypothesise that interval training on a cycloergometer or treadmill can limit exercise-induced desaturation in COPD patients.

The aim of the study is to observe the evolution of pulsed oxygen saturation between a continuous training session and a interval training session.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

COPD Behavior Chronic Disease Desaturation of Blood Disease Attributes Exercise Lung Diseases Lung Diseases, Obstructive Motor Activity Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Pulmonary Rehabilitation Respiratory Tract Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Groupe Hospitalier du Havre

Le Havre, Normandy, 76290, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • a diagnosis of COPD
  • participating in a pulmonary rehabilitation programme
  • with an exercise-induced desaturation less than 90%
  • no oxygen supplementation

Exclusion criteria

  • Under 18 years of age
  • Pregnant woman
  • Person not affiliated to a health insurance regime or not benefiting from a social security regime
  • Patient under curatorship, guardianship or safeguard of justice
  • Patient speaking a language other than French
  • Patient with severe hypoxaemia (SpO2 ≤ 80%) during exercise
  • Patient having had a moderate or severe exacerbation (hospitalisation for respiratory reasons) in the previous 4 weeks
  • Patients with orthopaedic, rheumatic, vascular or neurological pathology limiting their ability to make an effort
  • Breastfeeding women

Treatment and study plan

Continuous training session

Other

Continuous training consists of a 5 minute warm up, 5 minute cool down and 20 minutes of moderate intensity work. The workload is set at 60% of the patient's maximum power

Interval training session

Other

Interval training consists of a 5-minute warm-up, a 5-minute cool-down and 20 minutes of alternating 60 seconds of high-intensity work (100% of the maximum power recorded in the incremental test that was carried out when the patient was admitted to the pulmonary rehabilitation department) and 60 seconds of unloaded pedalling or rest.

Primary outcomes

  1. Difference in oxygen pulsed saturation

    Time frame: One week

    Difference in minimum saturation during both exercise, the measurement will be performed with a pulse oximeter (Spirodoc, MIR)

Secondary outcomes

  1. Difference in oxygen pulsed saturation

    Time frame: One week

    Difference in mean pulsed oxygen saturation and the time spent with a pulsed oxygen saturation below 90% during the two training sessions. The measurement will be performed with a pulse oximeter (Spirodoc, MIR)

  2. Difference in peripheral muscle oxygenation

    Time frame: One week

    Muscle oxygenation (arbitrary unit) will be evaluated using Near-infrared spectroscopy technology. the measurement will be performed with a Near Infrared spectroscopy (Portamon, Artinis Medical Systems)

  3. Difference in respiratory rate

    Time frame: One week

    Difference in respiratory rate will be measured breath-by-breath using a portable spirometer (Spirodoc, MIR)

  4. Difference in tidal volume

    Time frame: One week

    Difference in tidal volume will be measured breath-by-breath using a portable spirometer (Spirodoc, MIR)

  5. Difference in inspiratory capacity

    Time frame: One week

    Difference in inspiratory capacity will be measured using a portable spirometer (Spirodoc, MIR)

  6. Difference in Dyspnea

    Time frame: One week

    Dyspnea peak during exercise using the modified Borg scale 0-10, 0 no dyspnea, 10 maximal dyspnea

  7. Difference in muscle discomfort

    Time frame: One week

    Muscle discomfort peak during exercise using the modified Borg scale 0-10, 0 no dyspnea, 10 maximal dyspnea

Sponsors and collaborators

Lead sponsor

Groupe Hospitalier du Havre

Other

Collaborators

  • Combret Yann
  • Machefert Margaux
  • Medrinal Clement

Registry information

Official study title

Evolution of Pulsed Oxygen Saturation Throughout an Interval Training Session Compared to a Continuous Training Session in Patients With Chronic Obstructive Pulmonary Disease With Exercise-induced Oxygen Desaturation.

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Apr 24, 2023
Registry last updated
Jan 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.