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Completed

NCT Number: NCT04890080

Resting Heart Rate in Chronic Obstructive Pulmonary Disease

110 COPD patients who were participated in the PR program were included in the study. Resting Heart Rate , pulmonary functions, functional capacity, perception of dyspnea, quality of life and psychological symptoms compared before and after PR.

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Key information

Conditions

Pulmonary Rehabilitation Behavior COPD Chronic Disease Disease Attributes Exercise Lung Diseases Lung Diseases, Obstructive Motor Activity Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases Resting Heart Rate

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

In many studies, it has been reported that baroreceptor activity and heart rate variability decrease and resting heart rate (RHR) increases in COPD patients due to changes in cardiac autonomic function. Among the recommendations regarding pulmonary rehabilitation (PR) and exercise training in COPD patients, approaches such as including practices targeting RHR and developing implementation strategies that improve the cardiovascular system are recommended. The primary aim of our study is to examine the effect of comprehensive exercise training consisting of breathing, aerobic and strengthening exercises on RHR in COPD patients, and secondarily to determine the factors that affect RHR change after PR in COPD patients.

110 COPD patients who were participated in the PR program were included in our retrospective study. Resting Heart Rate , pulmonary functions, functional capacity, perception of dyspnea, quality of life and psychological symptoms compared before and after PR.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed with COPD according to GOLD and completed the 2-day / 8-week PR program

Exclusion criteria

  • With cardiovascular disease
  • With additional diseases such as diabetes
  • Receiving medical treatment that affects the autonomic nervous system
  • Patients receiving long-term oxygen therapy

Treatment and study plan

Pulmonary Rehabilitation

Other

Exercise training consisted of supervised breathing, aerobic, strengthening and stretching exercises for 8 weeks, 2 days a week. Breathing exercises included pursed lip, diaphragmatic, thoracic expansion and basal expansion exercises. Strength training included the lower and upper extremities, and it was performed 8-10 repetitions, either against gravity or using free weight, according to patient tolerance.

Primary outcomes

  1. Resting Heart Rate

    Time frame: 1 minute

    number of beats per minute

Secondary outcomes

  1. Functional Capacity

    Time frame: Change from baseline six minute walk distance at 8 week

    Six Minute- walk test

  2. Dyspnea Assessment

    Time frame: Change from baseline dyspnea at 8 week

    Medical Research Council Scale(MRC); the MRC dyspnea scale is a questionnaire that consists of five statements about perceived breathlessness. (min 1- max 5 point) Higher scores mean a worse outcome.

  3. Quality of Life Assessment

    Time frame: Change from baseline dyspnea at 8 week

    St. George Respiratory Questionnaire; Scores range from 0 to 100, with higher scores indicating more limitations.

  4. Anxiety and Depression

    Time frame: Change from baseline dyspnea at 8 week

    Hospital Anxiety and Depression (HAD); The HADS questionnaire has seven items each for depression and anxiety subscales. Scoring for each item ranges from zero to three, with three denoting highest anxiety or depression level. A total subscale score of >8 points out of a possible 21 denotes considerable symptoms of anxiety or depression.

Sponsors and collaborators

Lead sponsor

Izmir Katip Celebi University

Other

Registry information

Official study title

Improvement of Resting Heart Rate After Exercise Training and Its Predictors in Chronic Obstructive Pulmonary Diseases

Important dates

Study start
2017
Primary completion
2019
Study completion
2021
First posted
May 18, 2021
Registry last updated
May 18, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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