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Completed

NCT Number: NCT02050945

The Effects of Physical Exercise Training in Patients With Chronic Obstructive Pulmonary Disease

The purpose of the present project is to investigate the physiological effects of two different types of exercise training in COPD patients. The patients will be examined before, during and after 8 weeks of training to evaluate the effect of different types of skeletal muscle stimulation on health related quality of life, 6 min walking distance, flow mediated dilation, and histological properties of skeletal muscle cells, regarding oxidative capacity, fiber type, purinergic receptor amounts and measures of systemic inflammation. The study will test the hypothesis that:

Resistance training is superior to endurance training in patients with COPD

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Key information

Conditions

COPD Behavior Chronic Disease Disease Attributes Exercise Lung Diseases Lung Diseases, Obstructive Motor Activity Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Resistance Training Respiratory Tract Diseases

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre of Physical Activity Resarch, Copenhagen, Capital Region, Denmark

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • FEV1/FVC fixed ratio <0.70, FEV1: <60% of predicted and MRC > or equal to 3
  • Arterial oxygen saturation at rest> 90%, BMI >18, LVEF> 45.
  • Age: 40 - 80 years

The medical treatment will be continued unchanged during the study and additional prednisolone and /or antibiotic treatment will be prescribed in case of acute exacerbation.

Exclusion criteria

  • Unstable ischemic heart disease, severe heart valve failure, pulmonary emboli, severe heart failure, severe infections, musculoskeletal disorders, malignant disease, contraindicated medicine as MAO inhibitors and anticoagulants.

Treatment and study plan

Resistance training

Behavioral

Other names: Strength training, skeletal muscle, exercise, muscle training

Endurance training

Behavioral

Primary outcomes

  1. Skeletal muscle function

    Time frame: At baseline and after 8 weeks of traning

    Muscle biopsy

Secondary outcomes

  1. Flow mediated dilation

    Time frame: Change from baseline at 8 weeks

    Endothelium function

  2. Body composition

    Time frame: Change from baseline at 8 weeks

    DEXA scan

  3. 6 min walking test

    Time frame: Change from baseline at 8 weeks

  4. Health Related Quality of Life - COPD assessment test (CAT)

    Time frame: Change from baseline at 8 weeks

Sponsors and collaborators

Lead sponsor

Rigshospitalet, Denmark

Other

Collaborators

  • Copenhagen University Hospital, Hvidovre

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Jan 31, 2014
Registry last updated
Apr 21, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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