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Completed

NCT Number: NCT02123940

Treatment Strategy in Patients With High-risk of Postextubation Distress in ICU Based on a Lung Ultrasound Score Versus Standard Strategy

Prospective, randomized clinical multicentric study in ICU during weaning from mechanical ventilation.

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Key information

Conditions

Adult Patients Ventilated More Than 48 h

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

CHU de Clermont-Ferrand

Clermont-Ferrand, 63003, France

About this study

Prospective randomized clinical multicentric study on ICU comparing a treatment strategy (nasal humidified high flow therapy and Noninvasive Ventilation) in patients with high-risk of postextubation distress in ICU based on a Lung Ultrasound Score VERSUS standard strategy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients ventilated more than 48 h
  • Stable respiratory and hemodynamic conditions for SBT
  • Consent of patients
  • Arterial line

Exclusion criteria

  • severe COBP
  • Laryngeal dyspnea
  • Tracheostomy
  • Arrhythmia
  • No echogenicity
  • Paraplegia >T8

Treatment and study plan

lung ultrasound score

Device

Prospective randomized clinical multicentric study on ICU comparing a treatment strategy (nasal humidified high flow therapy and Noninvasive Ventilation) in patients with high-risk of postextubation distress in ICU based on a Lung Ultrasound Score VERSUS standard strategy

Primary outcomes

  1. Incidence of postextubation distress

    Time frame: during 48 hour (at day 1)

    postextubation period requiring a ventilatory support (reintubation or curative Noninvasive ventilation).

Secondary outcomes

  1. Number of ventilator-free-days

    Time frame: at day 1 (after extubation)

  2. Length of stay in ICU

    Time frame: at day 1

  3. Mortality in ICU

    Time frame: at day 1

  4. Extubation failure

    Time frame: at day 7

    Extubation failure within the 7 days following planned extubation

Sponsors and collaborators

Lead sponsor

University Hospital, Clermont-Ferrand

Other

Collaborators

  • Centre Hospitalier Universitaire de Saint Etienne
  • Hospices Civils de Lyon
  • Pitié-Salpêtrière Hospital
  • University Hospital, Grenoble
  • University Hospital, Marseille

Registry information

Acronym: WIN IN WEAN

Important dates

Study start
2014
Primary completion
2018
Study completion
2018
First posted
Apr 28, 2014
Registry last updated
Apr 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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