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Completed

NCT Number: NCT01098773

Pulmonary and Cardiac Ultrasound During Weaning From Mechanical Ventilation

Prospective observational clinical multicentric study in ICU with ventilated patients requiring chest ultrasound analysis.

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Key information

Conditions

Adult Patients Ventilated More Than 48 h Arterial Line Consent of Patients Stable Respiratory and Hemodynamic Conditions for SBT

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Clermont-Ferrand

Clermont-Ferrand, 63003, France

About this study

Prospective observational clinical multicentric study on ICU ventilated patients requiring chest ultrasound analysis during weaning from mechanical ventilation with 48 hours of follow-up. Studying variations of cardiac markers

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients ventilated more than 48 h
  • Stable respiratory and hemodynamic conditions for SBT
  • Consent of patients
  • Arterial line

Exclusion criteria

  • Laryngeal dyspnea
  • Tracheostomy
  • Arythmya
  • No echogenicity
  • Paraplegia >T8

Treatment and study plan

Primary outcomes

  1. Compare the change in pulmonary aeration during the test of weaning from mechanical ventilation (before, at the end, and 4-6 h after) between patients requiring re-ventilation before the 48th hour, and those weaned permanently.

    Time frame: before, at the end, and 4-6 h after

    Compare the change in pulmonary aeration during the test of weaning from mechanical ventilation (before, at the end, and 4-6 h after) between patients requiring re-ventilation before the 48th hour, and those weaned permanently.

Secondary outcomes

  1. Studying variations, during weaning from mechanical ventilation, of pressure of left ventricle filling (E / Ea) coupled with those of plasma BNP.

    Time frame: in the 4-6 early hours

    Studying variations, during weaning from mechanical ventilation, of pressure of left ventricle filling (E / Ea) coupled with those of plasma BNP.

  2. Assessing the effects of E / Ea and BNP variations on the success or failure in the 4-6 early hours.

    Time frame: in the 4-6 early hours.

    Assessing the effects of E / Ea and BNP variations on the success or failure in the 4-6 early hours.

  3. Compare the variations of lung ultrasound score during the test of the weaning from mechanical ventilation between patients failed the spontaneous breathing test (SBT) and those extubated after successful SBT.

    Time frame: in the 4-6 early hours

    Compare the variations of lung ultrasound score during the test of the weaning from mechanical ventilation between patients failed the spontaneous breathing test (SBT) and those extubated after successful SBT.

  4. Comparison of levels epithelial and endothelial markers

    Time frame: at h0, h1, h4, h6

  5. Constitution serum bank for epithelial (sRAGE) markers dosages

    Time frame: at h0, h1, h4, h6

  6. constitution serum bank for endothelial (angiopoietin) markers dosages

    Time frame: at h0, h1, h4, h6

Sponsors and collaborators

Lead sponsor

University Hospital, Clermont-Ferrand

Other

Collaborators

  • Groupe Hospitalier Pitie-Salpetriere

Registry information

Acronym: PULCO

Important dates

Study start
2010
Primary completion
2010
Study completion
2010
First posted
Apr 5, 2010
Registry last updated
Jul 8, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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