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Completed

NCT Number: NCT01702779

Nasal Humidified High Flow Oxygen During Weaning From Mechanical Ventilation : Ultrasonography Study

This is a prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

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Key information

Conditions

Adult Patients Ventilated More Than 48 h Arterial Line Consent of Patients Stable Respiratory and Hemodynamic Conditions for SBT

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Clermont-Ferrand

Clermont-Ferrand, France

About this study

Prospective randomized clinical multicentric study on ICU (Intensive Care University) comparing nasal humidified high flow therapy versus standard oxygen with Lung Ultrasound Score during weaning from mechanical ventilation

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients ventilated more than 48 h
  • Stable respiratory and hemodynamic conditions for SBT
  • Consent of patients
  • Arterial line

Exclusion criteria

  • COBP
  • Laryngeal dyspnea
  • Tracheostomy
  • Arythmya
  • No echogenicity
  • Paraplegia >T8

Treatment and study plan

Mechanical ventilation

Other

Prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

Primary outcomes

  1. variations of lung ultrasound score

    Time frame: 24 hours after extubation

Secondary outcomes

  1. Lung ultrasound score

    Time frame: at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation

  2. rates of patients with postextubation distress

    Time frame: during the 48th post-extubation

  3. Electrical Impedance tomography

    Time frame: at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation

  4. Epithelial and endothelial biomarkers

    Time frame: at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation

Sponsors and collaborators

Lead sponsor

University Hospital, Clermont-Ferrand

Other

Collaborators

  • Pitié-Salpêtrière Hospital

Registry information

Acronym: HiFloLUS

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Oct 8, 2012
Registry last updated
Dec 2, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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