Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07618884

TransREctus Sheath PrePeritoneal Procedure (TREPP) for Inguinal Hernia Repair

Inguinal hernia repair remains one of the most commonly performed surgical procedures worldwide. Tension-free repair with mesh augmentation is the predominant treatment option, either achieved by preperitoneal laparoscopic hernioplasty or Lichtenstein procedure (LP). As the recurrence rate is reduced to less than 5 % after mesh repair, nowadays, long-term morbidity associated with open inguinal hernia repair is mainly related to chronic postoperative inguinal pain (CPIP). Despite many hypotheses about the possible causes for CPIP, there is now consensus that involvement of inguinal nerves plays a major role.

The trans rectus sheath extra-peritoneal procedure (TREPP) is a minimally invasive open approach utilizing the rectus sheath to access the preperitoneal space. It has shown promise in providing effective repair with potential advantages in cosmesis, postoperative pain, and recurrence rates. It is a medial approach avoiding the interference with the course of all (three) inguinal nerves through lateral abdominal wall.

Recruiting

Interested in participating?

Request Info

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine-Assiut University -Assiut-Egypt

Asyut, Asyut Governorate, 71515, Egypt

Location status: Recruiting

Location contact

Mohamad Raafat, MD

CONTACT

About this study

This is a prospective cohort study

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults with primary unilateral or bilateral inguinal hernia

Exclusion criteria

  • Strangulated hernias.
  • Severe comorbidities precluding surgery ((ASA Class IV,V)

Treatment and study plan

trans rectus sheath extra-peritoneal procedure (TREPP)

Procedure

The TREPP technique, a minimally invasive open approach utilizing the rectus sheath to access the preperitoneal space

Primary outcomes

  1. Recurrence rate

    Time frame: through study completion, an average of 1 year

    Number and percentage of patients with recurrence of hernia after surgery

Secondary outcomes

  1. Incidence of chronic postoperative inguinal pain

    Time frame: 3 months after surgery

    Number and percentage of patients with groin pain that lasts more than three months after inguinal hernia surgery

Study contacts

Contact information is provided by the study sponsor or research team.

Faculty of Medicine-Assiut University

CONTACT

Mohamad Raafat, MD

CONTACT

[email protected]

0201067877622

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

TransREctus Sheath PrePeritoneal Procedure (TREPP) for Inguinal Hernia Repair: A Single-center Prospective Study.

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 1, 2026
Registry last updated
Jun 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.