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NCT Number: NCT07473583

Pneumoperitoneum Duration and Bicarbonate Changes in Laparoscopic Hernia Surgery

The goal of this observational study is to learn how the length of pneumoperitoneum during laparoscopic inguinal hernia surgery may affect changes in blood bicarbonate levels. Pneumoperitoneum is the use of carbon dioxide gas to create space inside the abdomen during laparoscopic surgery.

The main question this study aims to answer is whether a longer pneumoperitoneum time is associated with changes in blood bicarbonate levels after surgery.

Participants are adults undergoing laparoscopic inguinal hernia repair as part of their routine medical care. Researchers will measure blood gas values, including bicarbonate levels, before surgery and again two hours after surgery. The change in bicarbonate levels will be compared with the duration of pneumoperitoneum during the operation.

The results of this study may help improve the understanding of metabolic changes that occur during laparoscopic surgery.

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Key information

Conditions

Hernia, Inguinal Digestive System Diseases Hernia Hernia, Abdominal Inguinal Hernia Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Peritoneal Diseases Pneumoperitoneum

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

Carbon dioxide pneumoperitoneum is routinely used during laparoscopic surgery to provide adequate visualization and working space. However, absorption of carbon dioxide and increased intra-abdominal pressure may influence acid-base balance during the perioperative period. These physiological changes may be reflected in blood gas parameters such as pH, partial pressure of carbon dioxide (pCO2), and serum bicarbonate levels.

This prospective observational study aims to evaluate the relationship between pneumoperitoneum duration and perioperative changes in serum bicarbonate levels in patients undergoing laparoscopic inguinal hernia repair using the transabdominal preperitoneal (TAPP) technique.

Adult patients undergoing elective laparoscopic inguinal hernia repair will be included in the study. Blood gas measurements will be obtained before surgery and at the second postoperative hour. Serum bicarbonate levels will be recorded, and the difference between preoperative and postoperative measurements (ΔHCO3-) will be calculated.

The primary outcome of the study is the change in serum bicarbonate levels between the preoperative and postoperative second-hour measurements. Secondary outcomes include postoperative pain scores, postoperative acid-base parameters such as pH and pCO2, and early postoperative complications within the first 24 hours.

Pneumoperitoneum duration will be recorded intraoperatively and analyzed for its association with perioperative metabolic changes. The findings of this study may contribute to a better understanding of metabolic alterations occurring during laparoscopic surgery and their potential clinical implications.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 years
  • Patients undergoing laparoscopic inguinal hernia repair using the TAPP technique
  • Ability to provide informed consent

Exclusion criteria

  • Pregnancy
  • Severe cardiovascular disease
  • Renal insufficiency
  • Patients requiring additional intra-abdominal surgical procedures
  • Strangulated inguinal hernia requiring bowel resection

Treatment and study plan

Laparoscopic Inguinal Hernia Repair (TAPP)

Procedure

Standard laparoscopic inguinal hernia repair performed using the transabdominal preperitoneal (TAPP) technique as part of routine clinical care. Pneumoperitoneum duration during the procedure will be recorded for analysis.

Primary outcomes

  1. Change in Serum Bicarbonate Level

    Time frame: Preoperative to postoperative 2 hours

    Difference between preoperative and postoperative second-hour serum bicarbonate levels measured by blood gas analysis in patients undergoing laparoscopic inguinal hernia repair.

    Unit of Measure: mmol/L

Secondary outcomes

  1. Postoperative Pain Score

    Time frame: Within 24 hours after surgery

    Postoperative pain intensity measured using the Visual Analog Scale (VAS). The scale ranges from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores represent greater pain severity.

    Unit of Measure: VAS score (0-10)

  2. Change in Arterial Blood pH

    Time frame: Preoperative to postoperative 2 hours

    Change in arterial blood pH measured during pneumoperitoneum.

    Unit of Measure: pH

  3. Early Postoperative Complications

    Time frame: Within 24 hours

    Early postoperative complications occurring within the first 24 hours after laparoscopic inguinal hernia repair.

  4. Change in Arterial Partial Pressure of Carbon Dioxide

    Time frame: Preoperative to postoperative 2 hours

    Change in arterial PaCO₂ levels measured intraoperatively.

    Unit of Measure: mmHg

Study contacts

Contact information is provided by the study sponsor or research team.

Bahar Canbay Torun, MD

CONTACT

[email protected]

+90 505 389 0489

Osman Sibic, MD

CONTACT

[email protected]

+90 534 617 72 53

Sponsors and collaborators

Lead sponsor

Haseki Training and Research Hospital

Other

Registry information

Official study title

Association Between Pneumoperitoneum Duration and Changes in Serum Bicarbonate Levels in Patients Undergoing Laparoscopic Inguinal Hernia Repair: A Prospective Observational Study

Acronym: TAPPHCO3

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 16, 2026
Registry last updated
Mar 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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