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NCT Number: NCT07706062

Total Lower Uterine Segmentectomy With Adjunctive Mechanical Towel Compression for the Surgical Management of Placenta Accreta Spectrum Disorders

The goal of this observational study is to evaluate the feasibility and safety of utilizing adjunctive mechanical towel compression during TLS-CCA, measured primarily by estimated intraoperative blood loss in patient with Maternal age 18-45 years - Singleton pregnancy - Antenatal diagnosis of PAS (ultrasound ± MRI) - Planned elective cesarean delivery - Candidate for uterine preservation via TLS-CCA - Provided written informed consent

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Key information

About this study

Placenta accreta spectrum (PAS) disorders, characterized by abnormal trophoblastic invasion into the myometrium, have seen a global rise in incidence primarily driven by increasing cesarean delivery rates. Massive obstetric hemorrhage remains the leading cause of maternal morbidity and mortality in these cases.

While cesarean hysterectomy is the traditional gold standard for severe PAS, uteruspreserving procedures are increasingly preferred by patients desiring future fertility. Total lower uterine segmentectomy with cervico-corporeal anastomosis (TLS-CCA) is a recognized conservative technique that involves excising the invaded lower segment and reconstructing the uterus. Despite removing the primary placental implantation site, diffuse bleeding from the highly vascularized remaining myometrial bed, dissected bladder flap, and pelvic collateral vessels often persists. While traditional compression sutures or specialized devices are utilized for hemostasis, they can be costly or technically challenging in distorted anatomies. This study introduces a novel, simple, and cost-effective approach: the use of tightly rolled sterile surgical towelsapplied as direct mechanical compression against the lower uterine segment and bladder bed during dissection and reconstruction.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Maternal age 18-45 years
  • Singleton pregnancy
  • Antenatal diagnosis of PAS (ultrasound ± MRI)
  • Planned elective cesarean delivery
  • Candidate for uterine preservation via TLS-CCA
  • Provided written informed consent

Exclusion criteria

  • Hemodynamic instability necessitating emergency hysterectomy
  • Placental invasion into adjacent pelvic organs requiring exenteration
  • Pre-existing severe coagulation disorders
  • Multiple gestation or major fetal anomalies
  • Patient refusal to participate

Treatment and study plan

Primary outcomes

  1. Estimated intraoperative blood loss

    Time frame: at operation

    Estimated intraoperative blood loss by (mL)

Secondary outcomes

  1. Blood transfusion requirements

    Time frame: intraoperative

    Blood transfusion requirements (units of packed RBCs and FFP)

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Total Lower Uterine Segmentectomy With Adjunctive Mechanical Towel Compression for the Surgical Management of Placenta Accreta Spectrum Disorders: A Case Series

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jul 15, 2026
Registry last updated
Jul 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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