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NCT Number: NCT07236710

Observation of Strategies in Placenta Accreta Spectrum Management

• Placenta accreta spectrum (PAS) disorders represent a significant obstetric challenge, characterized by abnormal adherence of the placenta to the uterine wall, leading to potentially life-threatening hemorrhage (ACOG 2020; RCOG 2018; Jauniaux 2019) during delivery. PAS includes placenta accreta (attachment to the myometrium), increta (invasion into the myometrium), and percreta (penetration through the uterine serosa, often involving adjacent organs). The incidence of PAS is rising globally, largely attributed to the increased rates of cesarean section and uterine surgeries (Bowman 2021).

Effective management of PAS is crucial to prevent severe maternal morbidity and mortality. The cornerstone of management remains surgical intervention, with cesarean hysterectomy being the traditional gold standard (Eller 2009; ACOG 2020), especially in cases of extensive invasion. However, conservative and fertility-preserving surgical techniques have emerged in recent years as viable alternatives in selected cases (Jauniaux 2019).

In Assiut university hospital, diverse surgical approaches are practiced depending on the extent of placental invasion, surgeons expertise, and patient fertility desires. These include cesarean hysterectomy, segmental uterine resection, the Triple-P procedure, and uterus-preserving methods such as leaving the placenta in situ. (ijrcog) A notable contribution to conservative PAS management in Egypt is the Placental Pouch Closure technique. This technique involves careful resection of the invaded uterine wall followed by multilayered closure of the resulting myometrial defect (the "placental pouch"), thereby controlling hemorrhage while preserving uterine integrity.

(Zahran et al. 2020) .

• This retrospective study aims to evaluate the pattern and outcomes of various surgical approaches used in the management of placenta accreta spectrum disorders over a 10-year period at a Assiut university hospital. Special attention will be paid to the adoption, safety, and effectiveness of conservative techniques

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Key information

Age range

18 year–50 year

Sex eligibility

Female

Study type

Observational

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • - Women diagnosed with PAS (accreta, increta, percreta).
  • Deliveries conducted at Women's Health Hospital.
  • Age 18-50 years.
  • Availability of complete medical records and operative details.

Exclusion criteria

  • - Patients with incomplete records or missing surgical reports.
  • Cases managed outside the hospital.

Treatment and study plan

Primary outcomes

  1. Patterns of management over time

    Time frame: 10 years

    Patterns of management of placenta Accreta in retrospective way on the last 10 years

Study contacts

Contact information is provided by the study sponsor or research team.

Abdelrahman Mahmoud Mohamed, Dr

CONTACT

[email protected]

+201143554484

Mohamed Ayman Ayman, Master

CONTACT

[email protected]

+201103934356

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Evolving Strategies in Placenta Accreta Spectrum Management: A Ten-Year Institutional Review

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Nov 19, 2025
Registry last updated
Nov 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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