TMS for iEEG Monitoring Recordings

The current study presents a unique opportunity to measure the direct effects of transcranial magnetic stimulation (TMS) by using intracranial electrodes to record neural activity in deep brain regions when TMS single pulses are delivered. If TMS can evoke downstream responses in neural networks of the human brain, it can be a feasible way to study circuit engagement and connectivity.

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Key information

Conditions

EEG TMS

Age range

21 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Pennsylvania

Philadelphia, Pennsylvania, 19107, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who received (or are scheduled to receive) intracranial electrode implantation surgery as part of standard clinical care or as participation in an ongoing research study for the treatment of neurological and/or psychiatric conditions at Pennsylvania Hospital
Adult patients, 21 to 75 years of age
Patients considered to be in a stable medical condition, in the opinion of the PI
Patients who are able to demonstrate comprehension of instructions in the English language, in the opinion of the PI
Patients who are able to provide informed consent and fully comply with all study requirements, in the opinion of the PI

Exclusion criteria

Patients with chronic alcohol abuse history
Patients who are unable to have an MRI scan
Patients who are unable to tolerate TMS
Patients with additional implanted devices, such as an aneurysm clip or a cardiac pacemaker, that would increase the TMS risk profile
Patients who are pregnant at the time of screening or patients who get pregnant during the course of the study
Patients with any past or present medical condition, disease, disorder, or injury that, in the opinion of the PI, may reduce or hinder the participant's ability to fully comply with all study requirements or may impact, compromise, or affect the integrity of the data or the results of the study

Treatment and study plan

Single Pulse TMS

Device

single pulse TMS will be administered when participants have intracranial electrodes implanted to measure neuronal activity.

Primary outcomes

Primary Endpoint #1 Brain Activity and Connectivity

Time frame: From enrollment to the end of study participation at 5 weeks

Observation of effects in brain activity and connectivity within and across regions of interest before and after TMS, as measured by intracranial EEG. The evoked response magnitude from the EEG at all features of the time-frequency analysis are used.
Primary Endpoint #2: Safety Feasibility

Time frame: From enrollment to end of study participation at 5 weeks.

Safety, as defined by the number of adverse events (AE)

Sponsors and collaborators

Lead sponsor

University of Pennsylvania

Other

Registry information

Official study title

Mapping Transcrnial Magnetic Stimulation (TMS) Responses Within the Brain Using Intracranial Electrophysiological Monitoring Recordings

Important dates

Study start: 2025
Primary completion: 2029
Study completion: 2029
First posted: Apr 9, 2026
Registry last updated: May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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