Multimodal Analysis of Early Biomarkers of the Impacts of Perinatal Asphyxia

Inclusion criteria

• Non-Perinatal Asphyxia Cohort:

The non-PA cohort includes:

• Full-term infants (born between 36 and 42 weeks of gestation), clinically "normal" and without PA. Infants must have birth weights within the normal range for their gestational age.
• Satisfactory Apgar scores at 1, 3, and 5 minutes, indicating good health.
• Meet specific biochemical biomarker criteria as defined by the study protocols.
• No major complications should occur during pregnancy or delivery.

• At-Risk Perinatal Asphyxia Cohort:

The at-risk PA cohort includes newborns who are:

• Identified by healthcare professionals as being at risk based on criteria that do not exceed the diagnostic thresholds for PA but whose combined assessment of maternal, fetal, and neonatal medical criteria suggests risk factors and early signs of potential PA,
• OR
• Classified as such based on biochemical markers identified in WP1 (see WP1).

• Confirmed Perinatal Asphyxia Cohort:

The PA cohort includes:

• Newborns diagnosed with PA and treated with hypothermia. The inclusion criteria for this group allow for various modes of delivery, complications during pregnancy and delivery, and a range of gestational ages, as long as they meet the criteria for PA.
• Birth weight must be ≥ 1800 g.
• Apgar scores at 1, 3, and 5 minutes must indicate potential complications or difficulties.
• Specific biochemical markers indicative of PA must be present

Exclusion criteria

• Full-term newborn not meeting inclusion criteria